The Houston Astros had the lowest run differential by a team in 2013, with a differential of -238 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Astros	-238	2013	162	.315	51	111	5,457	610	1,307	266	16	148	566	426	52	1,535	110	61	6,019	2,049	430	46	38	17	110	.240	.299	.375	.674
2	Twins	-174	2013	162	.407	66	96	5,564	614	1,346	285	15	151	590	533	52	1,430	52	33	6,210	2,114	451	29	32	20	103	.242	.312	.380	.692
3	Phillies	-139	2013	162	.451	73	89	5,456	610	1,355	255	32	140	578	417	53	1,205	73	29	6,014	2,094	427	57	31	41	131	.248	.306	.384	.690
4	Marlins	-133	2013	162	.383	62	100	5,449	513	1,257	219	31	95	485	432	56	1,232	78	29	6,020	1,823	345	57	26	31	131	.231	.293	.335	.627
5	Mariners	-130	2013	162	.438	71	91	5,558	624	1,318	249	17	188	597	529	31	1,353	49	23	6,172	2,165	454	26	28	21	122	.237	.306	.390	.695
6	White Sox	-125	2013	162	.389	63	99	5,563	598	1,385	237	19	148	574	411	34	1,207	105	42	6,075	2,104	404	19	48	23	124	.249	.302	.378	.680
7	Cubs	-87	2013	162	.407	66	96	5,498	602	1,307	297	18	172	576	439	67	1,230	63	32	6,077	2,156	487	43	30	28	120	.238	.300	.392	.693
8	Padres	-82	2013	162	.469	76	86	5,517	618	1,349	246	26	146	578	467	52	1,309	118	34	6,122	2,085	418	52	34	36	99	.245	.308	.378	.686
9	Mets	-65	2013	162	.457	74	88	5,559	619	1,318	263	32	130	593	512	51	1,384	114	35	6,207	2,035	425	53	32	40	106	.237	.306	.366	.672
10	Giants	-62	2013	162	.469	76	86	5,552	629	1,446	280	35	107	596	469	39	1,078	67	26	6,168	2,117	422	66	42	40	131	.260	.320	.381	.702
11	Rockies	-54	2013	162	.457	74	88	5,599	706	1,511	283	36	159	673	427	26	1,204	112	32	6,152	2,343	478	65	35	26	111	.270	.323	.418	.741
12	Brewers	-47	2013	162	.457	74	88	5,474	640	1,381	238	43	157	610	407	71	1,183	142	50	6,064	2,176	438	77	35	22	116	.252	.311	.398	.708
13	Blue Jays	-44	2013	162	.457	74	88	5,537	712	1,398	273	24	185	669	510	38	1,123	112	41	6,152	2,274	482	29	38	19	133	.252	.318	.411	.729
14	Yankees	-21	2013	162	.525	85	77	5,449	650	1,321	247	24	144	614	466	57	1,214	115	31	6,044	2,048	415	36	36	33	121	.242	.307	.376	.683
15	Diamondbacks	-10	2013	162	.500	81	81	5,676	685	1,468	302	31	130	647	519	43	1,142	62	41	6,331	2,222	463	50	43	51	160	.259	.323	.391	.715
16	Angels	-4	2013	162	.481	78	84	5,588	733	1,476	270	39	164	696	523	48	1,221	82	34	6,260	2,316	473	37	64	40	150	.264	.329	.414	.743
17	Nationals	30	2013	162	.531	86	76	5,436	656	1,365	259	27	161	621	464	40	1,192	88	28	6,047	2,161	447	68	39	35	115	.251	.313	.398	.710
18	Orioles	36	2013	162	.525	85	77	5,620	745	1,460	298	14	212	719	416	36	1,125	79	29	6,144	2,422	524	27	45	36	105	.260	.313	.431	.744
19	Royals	47	2013	162	.531	86	76	5,549	648	1,443	254	34	112	620	422	42	1,048	153	32	6,092	2,101	400	37	42	38	131	.260	.315	.379	.694
20	Rays	54	2013	163	.564	92	71	5,538	700	1,421	296	23	165	670	589	36	1,171	73	38	6,242	2,258	484	24	55	31	140	.257	.329	.408	.737
21	Pirates	57	2013	162	.580	94	68	5,486	634	1,346	273	35	161	603	469	88	1,330	94	42	6,134	2,172	469	62	29	41	120	.245	.313	.396	.709
22	Dodgers	67	2013	162	.568	92	70	5,491	649	1,447	281	17	138	618	476	57	1,146	78	28	6,143	2,176	436	71	48	45	130	.264	.326	.396	.722
23	Indians	83	2013	162	.568	92	70	5,465	745	1,391	290	23	171	711	562	51	1,283	117	36	6,165	2,240	484	31	56	19	106	.255	.327	.410	.737
24	Rangers	94	2013	163	.558	91	72	5,585	730	1,465	262	23	176	691	462	61	1,067	149	46	6,195	2,301	461	45	42	26	124	.262	.323	.412	.735
25	Reds	109	2013	162	.556	90	72	5,499	698	1,370	274	20	155	664	585	76	1,245	67	35	6,291	2,149	449	85	46	65	129	.249	.327	.391	.718