Since 2003, the New York Yankees have scored their most runs in a game against the Oakland Athletics on August 25, 2011, with 22 runs.

Interpreted as:

yankees most runs in a regular-season game since 2003

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	22	8/25/2011	NYY	vs	OAK	W 22-9	43	21	2	1	5	22	13	1	9	0	0	58	40	8	0	1	1	0	.488	.603	.930	1.534
2	Yankees	21	7/28/2015	NYY	@	TEX	W 21-5	46	19	5	1	2	20	10	2	11	0	0	58	32	8	0	0	0	1	.413	.534	.696	1.230
3	Yankees	21	7/22/2007	NYY	vs	TBD	W 21-4	48	25	4	1	6	20	7	1	8	3	0	56	49	11	0	0	0	1	.521	.589	1.021	1.610
4	Yankees	20	3/29/2025	NYY	vs	MIL	W 20-9	40	16	2	0	9	20	8	2	5	0	0	51	45	11	0	1	0	0	.400	.510	1.125	1.635
5	Yankees	20	9/15/2020	NYY	vs	TOR	W 20-6	41	16	5	0	6	20	7	2	9	0	0	50	39	11	0	0	0	0	.390	.500	.951	1.451
6	Yankees	20	8/30/2015	NYY	@	ATL	W 20-6	46	21	3	0	3	20	9	1	7	0	0	57	33	6	0	1	0	1	.457	.544	.717	1.261
7	Yankees	20	8/21/2009	NYY	@	BOS	W 20-11	49	23	8	1	2	20	5	0	5	0	0	54	39	11	0	0	0	1	.469	.519	.796	1.314
8	Yankees	20	6/21/2005	NYY	vs	TBD	W 20-11	46	23	4	1	6	20	4	0	5	0	0	51	47	11	0	1	1	0	.500	.529	1.022	1.551
9	Yankees	19	9/26/2008	NYY	@	BOS	W 19-8	44	20	7	0	3	18	5	2	5	1	0	54	36	10	0	3	0	1	.455	.500	.818	1.318
10	Yankees	19	4/18/2005	NYY	vs	TBD	W 19-8	45	20	4	0	3	19	7	2	3	0	0	54	33	7	0	0	1	0	.444	.537	.733	1.270
11	Yankees	18	6/12/2022	NYY	vs	CHC	W 18-4	41	17	4	0	4	18	7	0	7	0	0	48	33	8	0	0	0	0	.415	.500	.805	1.305
12	Yankees	18	8/3/2011	NYY	@	CWS	W 18-7	48	23	4	2	2	18	2	1	9	1	0	52	37	8	0	1	0	1	.479	.500	.771	1.271
13	Yankees	18	7/2/2008	NYY	vs	TEX	W 18-7	41	16	4	0	2	18	7	1	0	1	0	49	26	6	0	0	0	1	.390	.490	.634	1.124
14	Yankees	18	8/28/2004	NYY	@	TOR	W 18-6	44	19	4	0	6	18	7	1	11	0	1	52	41	10	0	0	0	0	.432	.519	.932	1.451
15	Yankees	18	5/27/2004	NYY	@	BAL	W 18-5	46	21	6	0	2	18	4	2	5	0	0	54	33	8	0	2	0	1	.457	.500	.717	1.217
16	Yankees	17	6/29/2019	NYY	@	BOS	W 17-13	45	19	7	0	3	17	6	0	11	0	0	51	35	10	0	0	0	1	.422	.490	.778	1.268
17	Yankees	17	7/30/2011	NYY	vs	BAL	W 17-3	48	24	6	1	2	17	4	0	7	0	0	52	38	9	0	0	0	1	.500	.538	.792	1.330
18	Yankees	17	7/22/2011	NYY	vs	OAK	W 17-7	38	17	1	0	2	17	9	1	10	2	0	49	24	3	0	1	0	1	.447	.551	.632	1.183
19	Yankees	17	7/21/2007	NYY	vs	TBD	W 17-5	41	20	8	0	2	17	3	0	3	1	0	47	34	10	2	1	0	1	.488	.511	.829	1.340
20	Yankees	17	4/29/2006	NYY	vs	TOR	W 17-6	41	15	3	0	4	16	9	0	9	2	0	50	30	7	0	0	0	0	.366	.480	.732	1.212
21	Yankees	17	9/13/2005	NYY	@	TBD	W 17-3	45	20	1	0	1	17	9	0	4	0	0	54	24	2	0	0	0	1	.444	.537	.533	1.070
22	Yankees	16	6/28/2024	NYY	@	TOR	W 16-5	43	18	5	0	2	15	2	0	8	0	0	46	29	7	0	1	0	1	.419	.435	.674	1.109
23	Yankees	16	7/6/2022	NYY	@	PIT	W 16-0	46	22	4	0	6	16	8	0	10	3	0	55	44	10	0	1	0	2	.478	.545	.957	1.502
24	Yankees	16	9/10/2017	NYY	@	TEX	W 16-7	44	18	5	1	4	15	3	2	2	0	0	50	37	10	0	1	0	1	.409	.460	.841	1.301
25	Yankees	16	6/10/2017	NYY	vs	BAL	W 16-3	40	18	6	0	5	16	5	1	7	0	0	46	39	11	0	0	0	1	.450	.522	.975	1.497