Since 2010, the New York Yankees have put up their most runs in a game against the Oakland Athletics on August 25, 2011, with 22 runs.

Interpreted as:

yankees most runs in a regular-season game since 2010

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	22	8/25/2011	NYY	vs	OAK	W 22-9	43	21	2	1	5	22	13	1	9	0	0	58	40	8	0	1	1	0	.488	.603	.930	1.534
2	Yankees	21	7/28/2015	NYY	@	TEX	W 21-5	46	19	5	1	2	20	10	2	11	0	0	58	32	8	0	0	0	1	.413	.534	.696	1.230
3	Yankees	20	3/29/2025	NYY	vs	MIL	W 20-9	40	16	2	0	9	20	8	2	5	0	0	51	45	11	0	1	0	0	.400	.510	1.125	1.635
4	Yankees	20	9/15/2020	NYY	vs	TOR	W 20-6	41	16	5	0	6	20	7	2	9	0	0	50	39	11	0	0	0	0	.390	.500	.951	1.451
5	Yankees	20	8/30/2015	NYY	@	ATL	W 20-6	46	21	3	0	3	20	9	1	7	0	0	57	33	6	0	1	0	1	.457	.544	.717	1.261
6	Yankees	18	6/12/2022	NYY	vs	CHC	W 18-4	41	17	4	0	4	18	7	0	7	0	0	48	33	8	0	0	0	0	.415	.500	.805	1.305
7	Yankees	18	8/3/2011	NYY	@	CWS	W 18-7	48	23	4	2	2	18	2	1	9	1	0	52	37	8	0	1	0	1	.479	.500	.771	1.271
8	Yankees	17	6/29/2019	NYY	@	BOS	W 17-13	45	19	7	0	3	17	6	0	11	0	0	51	35	10	0	0	0	1	.422	.490	.778	1.268
9	Yankees	17	7/30/2011	NYY	vs	BAL	W 17-3	48	24	6	1	2	17	4	0	7	0	0	52	38	9	0	0	0	1	.500	.538	.792	1.330
10	Yankees	17	7/22/2011	NYY	vs	OAK	W 17-7	38	17	1	0	2	17	9	1	10	2	0	49	24	3	0	1	0	1	.447	.551	.632	1.183
11	Yankees	16	6/28/2024	NYY	@	TOR	W 16-5	43	18	5	0	2	15	2	0	8	0	0	46	29	7	0	1	0	1	.419	.435	.674	1.109
12	Yankees	16	7/6/2022	NYY	@	PIT	W 16-0	46	22	4	0	6	16	8	0	10	3	0	55	44	10	0	1	0	2	.478	.545	.957	1.502
13	Yankees	16	9/10/2017	NYY	@	TEX	W 16-7	44	18	5	1	4	15	3	2	2	0	0	50	37	10	0	1	0	1	.409	.460	.841	1.301
14	Yankees	16	6/10/2017	NYY	vs	BAL	W 16-3	40	18	6	0	5	16	5	1	7	0	0	46	39	11	0	0	0	1	.450	.522	.975	1.497
15	Yankees	16	4/6/2016	NYY	vs	HOU	W 16-6	41	17	2	1	3	16	7	0	7	2	0	48	30	6	0	0	0	0	.415	.500	.732	1.232
16	Yankees	15	4/29/2025	NYY	@	BAL	W 15-3	48	19	4	0	6	14	4	2	9	0	0	54	41	10	0	0	0	0	.396	.463	.854	1.317
17	Yankees	15	4/28/2024	NYY	@	MIL	W 15-5	43	18	3	0	3	14	6	0	5	2	0	50	30	6	0	1	0	1	.419	.480	.698	1.178
18	Yankees	15	4/27/2024	NYY	@	MIL	W 15-3	45	19	2	0	4	15	6	1	7	0	0	53	33	6	0	1	0	1	.422	.491	.733	1.224
19	Yankees	15	5/12/2022	NYY	@	CWS	W 15-7	40	15	2	1	4	15	7	0	14	0	0	48	31	7	0	1	0	1	.375	.458	.775	1.233
20	Yankees	15	4/7/2019	NYY	@	BAL	W 15-3	40	15	4	0	7	15	9	1	3	0	0	50	40	11	0	0	0	2	.375	.500	1.000	1.500
21	Yankees	15	8/28/2015	NYY	@	ATL	W 15-4	40	16	5	0	3	15	8	1	6	0	0	50	30	8	0	1	1	2	.400	.500	.750	1.250
22	Yankees	15	4/21/2012	NYY	@	BOS	W 15-9	42	16	4	0	3	15	8	0	9	1	0	50	29	7	0	0	2	1	.381	.480	.690	1.170
23	Yankees	15	4/23/2011	NYY	@	BAL	W 15-3	40	14	3	0	5	15	5	1	6	0	0	46	32	8	0	0	0	1	.350	.435	.800	1.235
24	Yankees	14	7/29/2024	NYY	@	PHI	W 14-4	39	14	2	1	6	14	5	0	9	0	0	44	36	9	0	0	0	0	.359	.432	.923	1.355
25	Yankees	14	7/6/2024	NYY	vs	BOS	W 14-4	36	14	3	0	4	14	4	0	7	0	0	42	29	7	1	1	1	0	.389	.439	.806	1.245