Zack Wheeler has a 69-37 record with an ERA of 2.91 and 1,094 strikeouts in 157 appearances for the Phillies in his career.
| NAME | SEASON | TM | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Z. Wheeler | 2020 |  PHI | 11 | 4 | 2 | .667 | 11 | 2.92 | 53 | 0 | 0 | 0 | 71.0 | 67 | 23 | 26 | 3 | 16 | 7 | 0 | 2 | 288 | 0 | 6.72 | 2.03 | 3.31 | 0.38 | 18.4 | 5.6 | 1.17 | .306 | 3.30 | 65 | 3.21 | 71 | 8.49 | 10.3 |
| 2 | | Z. Wheeler | 2021 | PHI | 32 | 14 | 10 | .583 | 32 | 2.78 | 247 | 3 | 2 | 0 | 213.1 | 169 | 66 | 72 | 16 | 46 | 8 | 0 | 1 | 849 | 6 | 10.42 | 1.94 | 5.37 | 0.68 | 29.1 | 5.4 | 1.01 | .288 | 3.04 | 66 | 2.58 | 60 | 7.13 | 40.7 |
| 3 | | Z. Wheeler | 2022 | PHI | 26 | 12 | 7 | .632 | 26 | 2.82 | 163 | 0 | 0 | 0 | 153.0 | 125 | 48 | 52 | 13 | 34 | 7 | 0 | 1 | 607 | 1 | 9.59 | 2.00 | 4.79 | 0.76 | 26.9 | 5.6 | 1.04 | .287 | 3.06 | 70 | 2.88 | 71 | 7.35 | 19.8 |
| 4 | | Z. Wheeler | 2023 | PHI | 32 | 13 | 6 | .684 | 32 | 3.61 | 212 | 0 | 0 | 0 | 192.0 | 168 | 77 | 82 | 20 | 39 | 9 | 0 | 0 | 787 | 1 | 9.94 | 1.83 | 5.44 | 0.94 | 26.9 | 5.0 | 1.08 | .292 | 3.84 | 82 | 3.15 | 71 | 7.88 | 27.7 |
| 5 | | Z. Wheeler | 2024 | PHI | 32 | 16 | 7 | .696 | 32 | 2.57 | 224 | 0 | 0 | 0 | 200.0 | 139 | 57 | 62 | 20 | 52 | 8 | 0 | 0 | 787 | 8 | 10.08 | 2.34 | 4.31 | 0.90 | 28.5 | 6.6 | 0.96 | .246 | 2.79 | 62 | 3.12 | 75 | 6.26 | 22.4 |
| 6 | | Z. Wheeler | 2025 | PHI | 24 | 10 | 5 | .667 | 24 | 2.71 | 195 | 1 | 0 | 0 | 149.2 | 107 | 45 | 48 | 19 | 33 | 8 | 0 | 0 | 585 | 2 | 11.73 | 1.98 | 5.91 | 1.14 | 33.3 | 5.6 | 0.94 | .267 | 2.89 | 64 | 2.99 | 71 | 6.43 | 20.1 |
| Total | 157 | 69 | 37 | .651 | 157 | 2.91 | 1,094 | 4 | 2 | 0 | 979.0 | 775 | 316 | 342 | 91 | 220 | 47 | 0 | 4 | 3,903 | 18 | 10.06 | 2.02 | 4.97 | 0.84 | 28.0 | 5.6 | 1.02 | .279 | 3.14 | 69 | 2.96 | 69 | 7.12 | 140.9 |
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