Since 1901, the Chicago Cubs have the most games by a team, with 19,503 games.

Interpreted as:

MLB, team most regular-season games since 1901

	TEAM	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cubs	19,503	.505	9,799	9,603	663,118	85,075	172,139	29,604	5,685	14,409	78,254	60,933	4,709	102,374	11,869	3,095	743,996	256,340	49,698	12,289	2,947	3,531	10,014	.260	.325	.387	.712
2	Reds	19,500	.499	9,677	9,733	662,077	84,038	171,951	29,386	5,950	13,828	77,632	60,116	4,822	100,144	13,843	3,421	742,001	254,721	49,164	11,914	3,072	3,657	9,796	.260	.324	.385	.709
3	Tigers	19,498	.503	9,763	9,642	664,850	89,528	175,573	29,761	6,324	14,718	82,459	65,897	4,491	97,755	11,333	2,949	749,392	262,136	50,803	11,010	3,144	2,455	10,776	.264	.333	.394	.727
4	Cardinals	19,494	.522	10,118	9,272	666,138	86,583	176,828	30,639	6,336	12,650	79,705	60,602	4,775	96,194	13,301	3,632	746,013	258,089	49,625	11,331	3,167	3,784	10,213	.265	.330	.387	.717
5	Dodgers	19,485	.532	10,311	9,085	662,389	84,778	172,522	28,173	5,652	13,810	78,231	62,224	4,396	98,088	13,183	3,566	744,271	253,429	47,635	12,164	3,098	3,759	10,016	.260	.327	.383	.709
6	Twins	19,485	.481	9,329	10,047	664,643	85,656	174,210	29,927	6,347	12,162	78,871	62,720	5,220	95,456	12,102	3,104	745,970	253,317	48,436	10,198	3,189	2,670	11,047	.262	.329	.381	.710
7	Giants	19,484	.534	10,348	9,046	662,872	87,086	173,324	28,375	5,608	15,074	80,252	61,905	5,094	97,220	12,361	3,158	744,169	258,137	49,057	11,243	3,055	4,028	10,258	.261	.328	.389	.717
8	Pirates	19,482	.504	9,764	9,623	665,308	84,505	175,279	29,487	7,340	11,886	77,764	58,260	4,758	97,245	12,543	3,294	743,164	255,104	48,713	11,699	3,139	3,710	10,133	.263	.326	.383	.709
9	Orioles	19,476	.475	9,195	10,171	661,510	84,093	170,609	29,514	4,924	14,570	77,764	63,639	4,529	99,390	10,643	2,809	743,342	253,681	49,008	10,534	3,130	2,587	10,908	.258	.326	.383	.709
10	Guardians	19,474	.513	9,940	9,443	663,602	87,976	175,517	31,326	5,512	14,035	81,330	62,968	4,877	95,572	12,004	3,410	746,317	259,972	50,873	11,484	3,386	2,569	10,578	.264	.331	.392	.723
11	Braves	19,471	.491	9,504	9,860	661,986	82,180	170,350	28,142	4,798	14,292	75,960	60,197	4,419	97,919	10,385	3,083	741,405	250,964	47,232	11,897	2,906	3,665	10,451	.257	.322	.379	.701
12	White Sox	19,471	.498	9,654	9,714	659,233	84,558	171,086	28,385	5,559	12,414	77,750	62,440	5,286	93,032	13,672	3,496	742,590	247,831	46,358	12,385	3,246	2,468	10,600	.260	.327	.376	.703
13	Red Sox	19,463	.518	10,044	9,336	666,123	90,918	177,700	33,354	5,616	14,729	84,326	67,162	4,856	96,544	9,724	2,577	752,116	266,473	53,699	10,605	3,370	3,011	11,624	.267	.337	.400	.737
14	Phillies	19,445	.470	9,095	10,276	661,656	82,705	170,931	29,884	5,383	13,727	76,283	61,036	4,627	102,834	11,447	2,935	741,508	252,762	48,994	11,144	3,045	3,752	9,926	.258	.324	.382	.706
15	Athletics	19,437	.486	9,405	9,945	658,868	85,814	169,575	29,417	5,342	14,300	79,101	64,867	4,768	100,062	12,164	3,228	742,328	252,576	49,059	10,697	3,128	2,281	10,691	.257	.327	.383	.710
16	Yankees	19,176	.570	10,872	8,216	653,521	93,216	173,428	28,805	5,507	17,515	86,637	69,038	4,959	95,884	11,751	2,828	740,439	265,792	51,827	9,601	3,320	2,869	10,758	.265	.339	.407	.745
17	Angels	10,301	.495	5,093	5,205	349,413	44,557	89,283	15,434	1,822	9,375	41,937	32,685	2,891	63,909	6,113	3,120	391,331	136,486	26,631	3,547	2,795	2,500	7,947	.256	.322	.391	.713
18	Rangers	10,288	.476	4,899	5,383	351,200	46,294	90,502	16,150	1,902	10,322	43,749	33,253	2,746	66,121	6,037	2,869	393,030	141,422	28,374	2,972	2,859	2,267	7,861	.258	.324	.403	.727
19	Astros	10,141	.503	5,096	5,040	344,176	43,252	87,719	16,086	2,179	8,563	40,713	32,676	2,951	63,857	7,210	3,151	386,581	133,852	26,828	4,038	2,740	3,154	7,496	.255	.322	.389	.711
20	Mets	10,134	.484	4,899	5,227	342,866	41,892	85,672	15,312	1,825	8,750	39,466	32,799	2,919	65,915	5,998	2,747	385,240	130,884	25,887	4,001	2,655	3,159	7,537	.250	.318	.382	.700
21	Padres	9,008	.468	4,217	4,789	304,496	36,548	75,940	13,450	1,772	7,370	34,376	28,979	2,171	60,306	6,074	2,624	341,673	115,044	22,592	3,748	2,279	2,699	6,573	.249	.317	.378	.695
22	Brewers	9,004	.489	4,405	4,595	305,685	40,111	78,316	14,603	1,769	8,831	37,997	29,442	2,763	59,793	6,086	2,770	343,521	122,950	25,203	3,177	2,454	2,167	6,682	.256	.325	.402	.727
23	Nationals	9,000	.481	4,331	4,665	304,365	37,707	77,186	14,895	1,810	7,716	35,450	28,557	2,661	58,151	6,632	2,809	341,786	118,849	24,421	3,888	2,315	2,891	6,577	.254	.321	.390	.711
24	Royals	8,995	.477	4,290	4,703	307,598	39,324	80,723	15,123	2,302	7,131	37,129	26,312	2,512	52,884	7,161	2,922	341,504	121,843	24,556	2,388	2,694	1,879	6,853	.262	.323	.396	.719
25	Blue Jays	7,714	.500	3,855	3,856	264,282	35,737	68,775	13,744	1,503	8,407	33,909	24,510	2,472	49,724	4,621	1,979	294,945	110,746	23,654	1,526	2,155	1,418	6,026	.260	.326	.419	.745