Nolan Ryan had the most games pitched when striking out 18+ batters, with 5 games.

Interpreted as:

most 18+ strikeout regular-season games by a pitcher

	NAME	G	SO	W	L	W%	GS	ERA	CG	SHO	IP	H	ER	R	HR	BB	HBP	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Nolan Ryan N. Ryan	5	94	2	1	.667	5	1.38	3	0	52.0	28	8	9	1	31	0	1	217	3	16.27	5.37	3.03	0.17	43.3	14.3	1.13	.297	1.56	4.85
2	Randy Johnson R. Johnson	4	76	1	1	.500	4	1.80	2	1	35.0	25	7	7	2	7	0	0	135	0	19.54	1.80	10.86	0.51	56.3	5.2	0.91	.460	1.80	6.43
3	Roger Clemens R. Clemens	3	58	3	0	1.000	3	0.33	3	2	27.0	11	1	1	1	0	0	0	92	1	19.33	0.00		0.33	63.0	0.0	0.41	.303	0.33	3.67
4	Sandy Koufax S. Koufax	2	36	2	0	1.000	2	2.00	2	0	18.0	13	4	4	2	6	0	0	72	0	18.00	3.00	6.00	1.00	50.0	8.3	1.06	.393	2.00	6.50
5	Max Scherzer M. Scherzer	1	20	1	0	1.000	1	2.00	1	0	9.0	6	2	2	2	0	0	0	33	0	20.00	0.00		2.00	60.6	0.0	0.67	.364	2.00	6.00
6	Corey Kluber C. Kluber	1	18	1	0	1.000	1	0.00	0	0	8.0	1	0	0	0	0	1	0	26	0	20.25	0.00		0.00	69.2	0.0	0.13	.143	0.00	1.13
7	Ben Sheets B. Sheets	1	18	1	0	1.000	1	1.00	1	0	9.0	3	1	1	1	1	0	0	31	0	18.00	1.00	18.00	1.00	58.1	3.2	0.44	.182	1.00	3.00
8	Kerry Wood K. Wood	1	20	1	0	1.000	1	0.00	1	1	9.0	1	0	0	0	0	1	0	29	0	20.00	0.00		0.00	69.0	0.0	0.11	.125	0.00	1.00
9	David Cone D. Cone	1	19	1	0	1.000	1	0.00	1	1	9.0	3	0	0	0	1	0	0	31	0	19.00	1.00	19.00	0.00	61.3	3.2	0.44	.273	0.00	3.00
10	Ramon Martinez R. Martinez	1	18	1	0	1.000	1	0.00	1	1	9.0	3	0	0	0	1	0	0	31	0	18.00	1.00	18.00	0.00	58.1	3.2	0.44	.250	0.00	3.00
11	Bill Gullickson B. Gullickson	1	18	1	0	1.000	1	2.00	1	0	9.0	4	2	2	0	2	0	0	33	1	18.00	2.00	9.00	0.00	54.5	6.1	0.67	.308	2.00	4.00
12	Ron Guidry R. Guidry	1	18	1	0	1.000	1	0.00	1	1	9.0	4	0	0	0	2	0	0	33	0	18.00	2.00	9.00	0.00	54.5	6.1	0.67	.308	0.00	4.00
13	Tom Seaver T. Seaver	1	19	1	0	1.000	1	1.00	1	0	9.0	2	1	1	1	2	0	0	31	0	19.00	2.00	9.50	1.00	61.3	6.5	0.44	.111	1.00	2.00
14	Steve Carlton S. Carlton	1	19	0	1	.000	1	4.00	1	0	9.0	9	4	4	2	2	0	0	38	1	19.00	2.00	9.50	2.00	50.0	5.3	1.22	.467	4.00	9.00
15	Don Wilson D. Wilson	1	18	1	0	1.000	1	1.00	1	0	9.0	5	1	1	0	2	0	0	33	1	18.00	2.00	9.00	0.00	54.5	6.1	0.78	.385	1.00	5.00
16	Luis Tiant L. Tiant	1	19	1	0	1.000	1	0.00	1	1	10.0	6	0	0	0	0	0	0	36	0	17.10	0.00		0.00	52.8	0.0	0.60	.353	0.00	5.40
17	Chris Short C. Short	1	18	0	0		1	0.00	0	0	15.0	9	0	0	0	3	0	1	56	0	10.80	1.80	6.00	0.00	32.1	5.4	0.80	.257	0.00	5.40
18	Jim Maloney J. Maloney	1	18	0	1	.000	1	0.82	1	0	11.0	2	1	1	1	1	0	0	35	1	14.73	0.82	18.00	0.82	51.4	2.9	0.27	.067	0.82	1.64
19	Tom Cheney T. Cheney	1	21	1	0	1.000	1	0.56	1	0	16.0	10	1	1	0	4	0	0	62	1	11.81	2.25	5.25	0.00	33.9	6.5	0.88	.270	0.56	5.63
20	Warren Spahn W. Spahn	1	18	0	1	.000	1	1.80	1	0	15.0	10	3	3	1	2	0	1	57	0	10.80	1.20	9.00	0.60	31.6	3.5	0.80	.250	1.80	6.00
21	Bob Feller B. Feller	1	18	0	1	.000	1	4.00	1	0	9.0	7	4	4	0	7	1		42	0	18.00	7.00	2.57	0.00	42.9	16.7	1.56	.438	4.00	7.00
22	Jack Coombs J. Coombs	1	18	0	0		1		1	1	16.0	3		0	0	6	1		54	1	10.13	3.38	3.00	0.00	33.3	11.1	0.56	.103	0.00	1.69