Answered January 12th, 2020

Since 1960, Nolan Ryan has the highest 2 * runs allowed * strikeouts in a game, with 198 against the Tigers on June 4, 1977.

most 2*r*so/(r so) in a game by a pitcher since 1960
Interpreted as:
most 2*r*so/(r so) in a regular-season game by a pitcher since 1960

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