Warren Spahn had the most games pitched when facing 30+ batters, with 473 games.

Interpreted as:

most regular-season games by a player with 30+ tbf

	NAME	G	TBF	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Warren Spahn W. Spahn	473	16,662	332	116	.741	473	2.33	2,037	366	52	0	4142.1	3,510	1,072	1,195	285	1,063	27	0	39	54	4.43	2.31	1.92	0.62	12.2	6.4	1.10	.243	2.60	7.63
2	Gaylord Perry G. Perry	450	15,503	259	138	.652	447	2.24	2,578	293	47	0	3897.1	3,156	970	1,140	240	929	71	1	101	96	5.95	2.15	2.78	0.55	16.6	6.0	1.05	.250	2.63	7.29
3	Steve Carlton S. Carlton	430	14,634	274	107	.719	430	2.41	2,940	240	46	0	3593.0	2,969	964	1,107	198	1,199	36	0	113	128	7.36	3.00	2.45	0.50	20.1	8.2	1.16	.270	2.77	7.44
4	Phil Niekro P. Niekro	425	14,472	239	124	.658	425	2.56	2,248	233	42	0	3535.0	2,967	1,004	1,174	264	1,113	85	0	54	134	5.72	2.83	2.02	0.67	15.5	7.7	1.15	.251	2.99	7.55
5	Early Wynn E. Wynn	423	14,882	265	127	.676	422	2.62	1,811	287	48	0	3607.1	3,041	1,052	1,194	214	1,282	43	1	19	37	4.52	3.20	1.41	0.53	12.2	8.6	1.20	.245	2.98	7.59
6	Red Ruffing R. Ruffing	415	15,014	246	145	.629	414	3.13	1,638	329	41	0	3602.1	3,304	1,252	1,430	186	1,199	36	1		36	4.09	3.00	1.37	0.46	10.9	8.0	1.25	.261	3.57	8.25
7	Ted Lyons T. Lyons	410	15,204	241	154	.610	407	3.07	941	355	26	0	3628.2	3,686	1,239	1,505	170	891	26	2		36	2.33	2.21	1.06	0.42	6.2	5.9	1.26	.267	3.73	9.14
8	Robin Roberts R. Roberts	403	14,043	250	118	.679	403	2.64	1,798	292	42	0	3497.2	3,134	1,025	1,130	309	658	42	0	42	24	4.63	1.69	2.73	0.80	12.8	4.7	1.08	.251	2.91	8.06
9	Burleigh Grimes B. Grimes	400	14,632	241	131	.648	394	2.92	1,264	308	32	0	3467.1	3,482	1,126	1,434	106	990	76	5		63	3.28	2.57	1.28	0.28	8.6	6.8	1.29	.277	3.72	9.04
10	Bert Blyleven B. Blyleven	389	13,195	203	123	.623	389	2.42	2,538	231	55	0	3274.2	2,729	879	1,003	208	861	97	0	47	63	6.98	2.37	2.95	0.57	19.2	6.5	1.10	.266	2.76	7.50
11	Tom Seaver T. Seaver	385	12,914	239	86	.735	385	2.09	2,500	217	54	0	3269.0	2,430	758	840	204	885	45	0	81	75	6.88	2.44	2.82	0.56	19.4	6.9	1.01	.240	2.31	6.69
12	Nolan Ryan N. Ryan	380	13,094	212	124	.631	380	2.39	3,479	213	54	0	3182.0	2,136	845	981	152	1,578	94	0	48	150	9.84	4.46	2.20	0.43	26.6	12.1	1.17	.255	2.77	6.04
13	Bob Gibson B. Gibson	374	13,046	228	108	.679	374	2.38	2,636	248	53	0	3201.0	2,552	846	973	175	1,033	84	0	93	83	7.41	2.90	2.55	0.49	20.2	7.9	1.12	.261	2.74	7.18
14	Don Sutton D. Sutton	355	11,773	202	90	.692	355	2.28	2,069	168	54	0	2947.1	2,332	747	819	180	720	40	0	49	59	6.32	2.20	2.87	0.55	17.6	6.1	1.04	.246	2.50	7.12
15	Fergie Jenkins F. Jenkins	354	12,087	228	98	.699	353	2.54	2,175	247	40	0	3024.0	2,535	853	963	288	614	53	1	68	38	6.47	1.83	3.54	0.86	18.0	5.1	1.04	.251	2.87	7.54
16	Bob Feller B. Feller	350	12,594	241	85	.739	349	2.54	2,112	267	37	0	3049.0	2,394	860	944	148	1,325	48	1	2	55	6.23	3.91	1.59	0.44	16.8	10.5	1.22	.251	2.79	7.07
17	Lefty Grove L. Grove	348	12,776	249	79	.759	344	2.52	1,742	289	31	0	3080.1	2,872	862	1,023	112	839	28	3		28	5.09	2.45	2.08	0.33	13.6	6.6	1.20	.274	2.99	8.39
18	Bobo Newsom B. Newsom	336	12,326	186	110	.628	332	3.23	1,628	239	28	0	2888.0	2,631	1,037	1,179	133	1,267	38	2		39	5.07	3.95	1.28	0.41	13.2	10.3	1.35	.270	3.67	8.20
19	Earl Whitehill E. Whitehill	336	12,284	191	111	.632	335	3.51	1,062	218	16	0	2848.1	2,893	1,111	1,314	127	1,055	76	1		31	3.36	3.33	1.01	0.40	8.6	8.6	1.39	.278	4.15	9.14
20	Jim Palmer J. Palmer	334	11,413	208	82	.717	334	2.19	1,579	199	45	0	2858.2	2,252	697	763	177	851	25	0	26	56	4.97	2.68	1.86	0.56	13.8	7.5	1.09	.236	2.40	7.09
21	Sad Sam Jones S. Sam Jones	332	11,965	190	113	.627	331	2.98	927	240	33	0	2841.0	2,738	942	1,141	101	966	44	1		46	2.94	3.06	0.96	0.32	7.7	8.1	1.30	.266	3.61	8.67
22	Carl Hubbell C. Hubbell	330	11,721	224	83	.730	327	2.44	1,337	255	32	0	2888.2	2,628	784	921	168	541	40	3		34	4.17	1.69	2.47	0.52	11.4	4.6	1.10	.255	2.87	8.19
23	Eppa Rixey E. Rixey	329	11,786	199	112	.640	328	2.60	807	240	26	0	2860.2	2,827	828	1,043	48	607	47	1		51	2.54	1.91	1.33	0.15	6.8	5.2	1.20	.270	3.28	8.89
24	Jack Morris J. Morris	322	10,870	174	109	.615	322	3.01	1,775	173	27	0	2650.1	2,232	885	978	220	893	31	0	67	129	6.03	3.03	1.99	0.75	16.3	8.2	1.18	.253	3.32	7.58
25	Juan Marichal J. Marichal	322	11,064	218	71	.754	322	2.27	1,882	237	48	0	2783.0	2,292	702	830	207	527	28	0	61	39	6.09	1.70	3.57	0.67	17.0	4.8	1.01	.248	2.68	7.41