Ken Griffey Jr. has launched the most career homers when the count has been 2 and 2, with 74 homers.

Interpreted as:

most homeruns by a player on 2-2 counts all-time

	NAME	HR	G	AB	H	2B	3B	RBI	BB	HBP	SO	PA	TB	XBH	SH	SF	IBB	AVG	OBP	SLG	OPS
1	Ken Griffey Jr. K. Griffey Jr.	74	1,102	1,351	272	47	4	188	0	8	530	1,370	549	125	0	11	0	.201	.204	.406	.611
2	Albert Pujols A. Pujols	66	1,304	1,604	374	74	6	231	1	12	437	1,626	658	146	0	9	0	.233	.238	.410	.648
3	Manny Ramirez M. Ramirez	61	1,053	1,328	308	64	3	204	0	15	547	1,349	561	128	0	6	0	.232	.239	.422	.662
4	David Ortiz D. Ortiz	60	1,119	1,426	288	73	3	199	0	3	585	1,437	547	136	0	8	0	.202	.203	.384	.586
5	Alex Rodriguez A. Rodriguez	57	1,289	1,607	346	63	3	191	0	21	695	1,639	586	123	0	11	0	.215	.224	.365	.589
6	Giancarlo Stanton G. Stanton	56	863	1,108	182	36	1	124	0	8	607	1,119	388	93	0	2	0	.164	.170	.350	.520
7	Barry Bonds B. Bonds	56	904	1,034	234	55	8	168	0	6	379	1,051	473	119	0	11	0	.226	.228	.457	.686
8	Adam Dunn A. Dunn	55	1,038	1,330	196	40	0	129	0	7	788	1,344	401	95	0	7	0	.147	.151	.302	.453
9	Mike Trout M. Trout	52	855	1,114	240	46	7	126	1	13	540	1,135	456	105	0	7	1	.215	.224	.409	.633
10	Sammy Sosa S. Sosa	51	1,108	1,382	255	37	9	155	0	5	730	1,392	463	97	0	5	0	.185	.187	.335	.522
11	Chipper Jones C. Jones	48	960	1,145	247	41	2	136	0	0	459	1,146	436	91	0	1	0	.216	.216	.381	.596
12	Carlos Delgado C. Delgado	48	956	1,181	226	65	4	161	0	18	563	1,204	443	117	0	5	0	.191	.203	.375	.578
13	Jim Edmonds J. Edmonds	48	890	1,114	256	50	3	139	0	3	523	1,126	456	101	0	9	0	.230	.230	.409	.639
14	Manny Machado M. Machado	47	828	998	204	30	2	126	0	0	399	1,002	379	79	0	4	0	.204	.204	.380	.583
15	Edwin Encarnacion E. Encarnacion	47	927	1,139	233	39	0	117	0	12	425	1,156	413	86	0	2	0	.205	.212	.363	.575
16	Rafael Palmeiro R. Palmeiro	47	1,088	1,315	312	68	4	164	0	3	410	1,330	529	119	0	12	0	.237	.237	.402	.639
17	Ryan Howard R. Howard	46	772	971	171	26	2	133	0	4	555	987	339	74	0	11	0	.176	.177	.349	.527
18	Miguel Cabrera M. Cabrera	46	1,199	1,449	341	62	4	162	0	11	609	1,467	549	112	0	7	0	.235	.240	.379	.619
19	Jason Giambi J. Giambi	46	999	1,212	234	41	4	152	0	20	522	1,241	421	91	0	9	0	.193	.205	.347	.552
20	Jim Thome J. Thome	46	1,158	1,451	227	44	3	146	0	5	840	1,460	415	93	0	4	0	.156	.159	.286	.445
21	Paul Goldschmidt P. Goldschmidt	45	1,045	1,328	292	59	4	172	0	5	585	1,343	494	108	0	4	0	.220	.222	.372	.594
22	Mark McGwire M. McGwire	45	694	828	125	13	0	97	0	8	449	841	273	58	0	5	0	.151	.158	.330	.488
23	Gary Sheffield G. Sheffield	44	984	1,155	271	40	5	147	0	9	332	1,174	453	89	0	10	0	.235	.239	.392	.631
24	Freddie Freeman F. Freeman	43	986	1,215	265	68	1	150	0	12	519	1,229	464	112	0	2	0	.218	.225	.382	.607
25	Jermaine Dye J. Dye	43	831	1,057	222	43	3	130	0	4	399	1,066	400	89	0	5	0	.210	.212	.378	.590