The Philadelphia Phillies have lost the most games by a team, with 11,377 losses.

Interpreted as:

most regular-season losses by a team of all-time

	TEAM	L	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Phillies	11,377	10,276	.525	21,768	.475	744,803	96,669	193,917	33,539	6,687	14,285	86,881	67,963	5,440	105,940	15,016	2,926	833,161	283,685	54,511	11,925	3,030	3,747	9,904	.260	.326	.381	.706
2	Braves	11,017	11,165	.497	22,336	.503	764,721	99,821	198,564	32,218	6,309	15,138	86,859	67,769	5,090	100,780	14,125	3,072	853,166	288,814	53,665	12,691	2,895	3,663	10,427	.260	.323	.378	.701
3	Pirates	10,890	10,890	.500	21,920	.500	750,769	97,448	197,545	32,464	8,944	12,305	86,946	64,541	5,550	100,237	15,724	3,285	836,681	284,812	53,713	12,565	3,133	3,706	10,103	.263	.325	.379	.704
4	Reds	10,824	10,998	.496	21,961	.504	748,238	98,544	194,921	32,499	7,568	14,394	87,664	66,937	5,533	102,897	18,201	3,417	836,603	285,738	54,461	12,667	3,060	3,654	9,768	.261	.325	.382	.707
5	Cubs	10,818	11,394	.487	22,373	.513	765,626	103,020	200,483	33,862	7,369	15,351	88,597	68,788	5,304	105,590	15,857	3,083	855,675	295,136	56,582	13,029	2,928	3,525	9,991	.262	.326	.385	.711
6	Orioles	10,150	9,173	.525	19,433	.475	660,061	83,921	170,286	29,457	4,918	14,523	77,600	63,477	4,511	98,962	10,603	2,801	741,704	253,148	48,898	10,533	3,122	2,583	10,888	.258	.326	.384	.709
7	Dodgers	10,120	11,500	.468	21,759	.532	741,401	98,265	193,681	31,171	7,012	14,234	88,475	69,166	5,176	100,972	17,381	3,561	831,679	281,578	52,417	12,778	3,082	3,751	9,989	.261	.327	.380	.707
8	Giants	10,081	11,600	.465	21,844	.535	745,440	100,942	195,997	31,454	7,053	15,651	90,404	68,544	5,711	100,198	16,543	3,151	834,413	288,510	54,158	11,680	3,038	4,023	10,234	.263	.328	.387	.716
9	Cardinals	10,031	10,566	.487	20,728	.513	708,954	92,710	188,342	31,946	7,052	12,930	84,760	64,399	5,236	98,733	15,054	3,622	793,731	273,182	51,928	11,984	3,158	3,780	10,185	.266	.330	.385	.715
10	Twins	10,018	9,315	.518	19,442	.482	663,190	85,475	173,867	29,861	6,341	12,111	78,703	62,573	5,203	95,066	12,046	3,092	744,338	252,743	48,313	10,192	3,180	2,666	11,024	.262	.329	.381	.710
11	Athletics	9,927	9,383	.514	19,397	.486	657,490	85,623	169,229	29,337	5,342	14,246	78,917	64,747	4,756	99,695	12,149	3,220	740,804	251,988	48,925	10,690	3,121	2,276	10,672	.257	.327	.383	.710
12	White Sox	9,689	9,638	.501	19,430	.499	657,847	84,373	170,747	28,326	5,558	12,367	77,569	62,327	5,269	92,683	13,661	3,494	741,064	247,290	46,251	12,381	3,240	2,468	10,569	.260	.327	.376	.703
13	Tigers	9,619	9,746	.497	19,458	.503	663,496	89,354	175,252	29,704	6,313	14,677	82,299	65,756	4,477	97,380	11,323	2,946	747,871	261,613	50,694	11,010	3,132	2,451	10,754	.264	.333	.394	.727
14	Guardians	9,425	9,914	.487	19,430	.513	662,170	87,803	175,204	31,263	5,506	13,993	81,161	62,850	4,861	95,190	11,965	3,404	744,734	259,458	50,762	11,476	3,377	2,561	10,562	.265	.331	.392	.723
15	Red Sox	9,318	10,021	.482	19,422	.518	664,720	90,745	177,343	33,279	5,612	14,692	84,165	67,038	4,842	96,203	9,687	2,568	750,560	265,922	53,583	10,601	3,359	3,007	11,592	.267	.337	.400	.737
16	Yankees	8,204	10,842	.431	19,134	.569	652,112	92,978	173,071	28,745	5,505	17,431	86,403	68,857	4,947	95,463	11,705	2,815	738,820	265,119	51,681	9,600	3,304	2,859	10,731	.265	.339	.407	.745
17	Rangers	5,363	4,879	.524	10,248	.476	349,834	46,105	90,171	16,088	1,899	10,273	43,564	33,130	2,729	65,805	6,009	2,863	391,513	140,876	28,260	2,969	2,851	2,266	7,835	.258	.324	.403	.727
18	Mets	5,203	4,880	.516	10,091	.484	341,375	41,652	85,267	15,237	1,822	8,679	39,231	32,647	2,897	65,543	5,944	2,739	383,556	130,185	25,738	3,997	2,640	3,156	7,511	.250	.318	.381	.700
19	Angels	5,177	5,079	.505	10,259	.495	348,053	44,413	89,009	15,387	1,818	9,321	41,800	32,565	2,872	63,446	6,084	3,117	389,821	135,995	26,526	3,543	2,788	2,497	7,919	.256	.322	.391	.713
20	Astros	5,018	5,076	.497	10,099	.503	342,759	43,087	87,400	16,028	2,178	8,514	40,556	32,553	2,935	63,495	7,185	3,146	385,017	133,326	26,720	4,035	2,735	3,148	7,469	.255	.323	.389	.712
21	Padres	4,769	4,196	.532	8,967	.468	303,125	36,355	75,593	13,386	1,770	7,321	34,190	28,868	2,151	59,985	6,049	2,616	340,147	114,482	22,477	3,735	2,268	2,696	6,547	.249	.317	.378	.695
22	Royals	4,684	4,268	.523	8,954	.477	306,228	39,129	80,376	15,045	2,299	7,080	36,940	26,186	2,496	52,619	7,145	2,915	339,981	121,259	24,424	2,384	2,687	1,876	6,826	.262	.323	.396	.719
23	Nationals	4,641	4,313	.518	8,958	.482	302,980	37,535	76,859	14,834	1,801	7,670	35,289	28,461	2,651	57,739	6,600	2,799	340,281	118,305	24,305	3,886	2,303	2,890	6,546	.254	.321	.390	.711
24	Brewers	4,574	4,384	.511	8,962	.489	304,237	39,925	77,945	14,526	1,764	8,792	37,825	29,289	2,745	59,473	6,055	2,760	341,887	122,375	25,082	3,173	2,443	2,164	6,647	.256	.325	.402	.727
25	Mariners	4,003	3,666	.522	7,671	.478	261,673	34,066	67,210	12,513	1,262	7,836	32,364	24,796	2,390	50,381	5,102	2,184	292,910	105,755	21,611	1,960	2,091	1,680	5,728	.257	.324	.404	.729