Between the 2012 and 2015 seasons, the St. Louis Cardinals had the most wins by a team, with 375 wins.

Interpreted as:

most regular-season wins by an MLB team 2012 to 2015

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cardinals	375	273	.579	648	22,089	2,814	5,777	1,175	117	526	2,681	1,991	269	4,702	262	129	24,751	8,764	1,818	228	174	158	557	.262	.328	.397	.724
2	Dodgers	364	284	.562	648	21,874	2,671	5,638	1,115	104	575	2,549	2,039	230	4,806	379	156	24,551	8,686	1,794	249	159	155	523	.258	.325	.397	.722
3	Nationals	363	285	.560	648	22,021	2,776	5,599	1,090	92	684	2,609	1,999	181	5,165	351	109	24,601	8,925	1,866	233	167	145	469	.254	.319	.405	.725
4	Pirates	359	289	.554	648	22,065	2,664	5,557	1,081	129	627	2,543	1,894	306	5,250	369	186	24,656	8,777	1,837	241	150	165	460	.252	.318	.398	.715
5	Orioles	355	293	.548	648	22,261	2,875	5,639	1,078	66	854	2,763	1,715	199	5,056	225	103	24,438	9,411	1,998	120	143	112	496	.253	.311	.423	.733
6	Yankees	351	297	.542	648	22,037	2,851	5,529	1,046	82	748	2,716	2,037	238	4,750	383	109	24,618	8,983	1,876	120	186	103	473	.251	.319	.408	.726
7	Angels	350	298	.540	648	22,193	2,934	5,789	1,090	113	682	2,778	1,899	213	4,750	349	140	24,651	9,151	1,885	147	199	145	516	.261	.322	.412	.735
8	Athletics	346	302	.534	648	22,193	2,903	5,477	1,098	136	673	2,748	2,184	179	4,788	357	109	24,801	8,866	1,907	81	164	113	447	.247	.317	.399	.717
9	Tigers	345	302	.533	647	22,446	2,968	6,164	1,185	137	645	2,856	1,940	185	4,579	283	135	24,868	9,558	1,967	115	182	173	591	.275	.335	.426	.761
10	Giants	342	306	.528	648	22,198	2,708	5,834	1,112	173	478	2,570	1,836	160	4,579	334	128	24,608	8,726	1,763	225	189	151	500	.263	.321	.393	.714
11	Royals	342	306	.528	648	22,305	2,699	5,888	1,135	142	477	2,556	1,589	214	4,038	542	140	24,415	8,738	1,754	130	177	123	525	.264	.317	.392	.708
12	Rangers	339	310	.522	649	22,146	2,926	5,810	1,104	115	659	2,775	1,860	255	4,565	446	188	24,620	9,121	1,878	165	194	139	492	.262	.324	.412	.736
13	Rays	339	310	.522	649	21,937	2,653	5,458	1,087	109	624	2,533	2,123	244	4,928	357	154	24,621	8,635	1,820	120	197	110	529	.249	.319	.394	.713
14	Braves	336	312	.519	648	21,754	2,534	5,372	1,001	91	553	2,409	2,052	176	5,149	329	129	24,352	8,214	1,645	231	139	143	496	.247	.315	.378	.693
15	Reds	327	321	.505	648	21,942	2,602	5,411	1,081	97	625	2,475	1,977	217	5,018	410	152	24,577	8,561	1,803	281	160	179	429	.247	.313	.390	.703
16	Indians	326	321	.504	647	22,004	2,750	5,582	1,143	99	590	2,630	2,154	191	4,716	417	135	24,689	8,693	1,832	146	194	105	507	.254	.323	.395	.718
17	Blue Jays	323	325	.498	648	22,082	3,042	5,659	1,110	87	792	2,888	2,055	188	4,676	401	126	24,643	9,319	1,989	133	185	87	510	.256	.322	.422	.744
18	Mets	317	331	.489	648	22,008	2,581	5,332	1,119	89	571	2,474	2,019	215	5,188	345	132	24,585	8,342	1,779	205	138	167	466	.242	.310	.379	.689
19	Red Sox	315	333	.486	648	22,446	2,969	5,875	1,278	98	627	2,821	2,022	231	4,990	354	102	25,006	9,230	2,003	108	199	142	507	.262	.326	.411	.738
20	Mariners	309	339	.477	648	22,046	2,533	5,310	999	98	671	2,405	1,869	157	5,180	318	145	24,335	8,518	1,768	131	132	106	452	.241	.303	.386	.689
21	Brewers	307	341	.474	648	21,973	2,721	5,567	1,109	144	654	2,592	1,708	275	4,919	486	161	24,375	8,926	1,907	278	141	124	492	.253	.313	.406	.720
22	Diamondbacks	305	343	.471	648	22,339	2,754	5,757	1,157	159	567	2,610	1,946	160	4,885	373	169	24,839	8,933	1,883	213	181	169	517	.258	.319	.400	.719
23	Padres	303	345	.468	648	21,690	2,454	5,211	1,002	135	524	2,311	1,900	187	5,168	446	143	24,155	8,055	1,661	223	155	121	425	.240	.305	.371	.676
24	Cubs	297	351	.458	648	21,908	2,518	5,260	1,104	115	637	2,393	1,895	238	5,460	317	154	24,345	8,505	1,856	174	130	133	440	.240	.306	.388	.694
25	White Sox	297	351	.458	648	22,157	2,628	5,575	1,004	107	650	2,520	1,693	224	5,003	367	163	24,332	8,743	1,761	99	159	102	488	.252	.309	.395	.704