Joe Oeschger has the highest Game Score, with a Game Score of 153 against the Brooklyn Robins on May 1, 1920.

Interpreted as:

top 20 highest game scores by a player of all-time

	NAME	GSC	DATE	TM		OPP	DEC	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP
1	Joe Oeschger J. Oeschger	153	5/1/1920	BSN	vs	BKN		1	0.35	7	1	0	0	26.0	9	1	1	0	4	0	0		90	1
2	Leon Cadore L. Cadore	140	5/1/1920	BKN	@	BSN		1	0.35	7	1	0	0	26.0	15	1	1	0	5	0	0		96	0
3	Carl Hubbell C. Hubbell	132	7/2/1933	NYG	vs	SLN	W	1	0.00	12	1	1	0	18.0	6	0	0	0	0	0	0		59	0
4	Lefty Tyler L. Tyler	126	7/17/1918	CHC	vs	PHN	W	1	0.00	8	1	0	0	21.0	13	0	1	0	1	0	0		77	0
5	Walter Johnson W. Johnson	120	5/15/1918	WSH	vs	CWS	W	1	0.00	9	1	1	0	18.0	10	0	0	0	1	0	0		62	0
6	Phil Douglas P. Douglas	119	7/7/1915	BKN	vs	BSN		1	0.00	8	1	1	0	16.0	4	0	0	0	3	0	0		56	1
7	Tom Hughes T. Hughes	119	9/21/1901	CHO	vs	BSN	W	1	0.00	13	1	1	0	17.0	8	0	0	0	5	0	0		60	0
8	Vern Law V. Law	118	7/19/1955	PIT	vs	MIL		1	0.50	12	0	0	0	18.0	9	1	2	1	2	0	0	0	64	1
9	Art Nehf A. Nehf	118	8/1/1918	BSN	vs	PIT	L	1	0.86	8	1	0	0	21.0	12	2	2	0	5	0	0		77	0
10	Babe Adams B. Adams	117	7/17/1914	PTN	vs	NYG	L	1	1.29	6	1	0	0	21.0	12	3	3	1	0	0	0		75	0
11	Dean Chance D. Chance	116	6/6/1964	LAA	vs	NYY		1	0.00	12	0	0	0	14.0	3	0	0	0	2	0	0	0	47	0
12	Roy Parmelee R. Parmelee	116	4/29/1936	SLN	vs	NYG	W	1	0.53	9	1	0	0	17.0	6	1	1	0	4	0	0		57	0
13	Jim Scott J. Scott	116	4/20/1912	CWS	@	SLA		1	0.00	13	1	1	0	15.0	6	0	0	0	2	0	0		51	0
14	Tom Cheney T. Cheney	115	9/12/1962	WSH	@	BAL	W	1	0.56	21	1	0	0	16.0	10	1	1	0	4	0	0	0	62	1
15	Johnny Vander Meer J. Vander Meer	115	9/11/1946	CIN	@	BKN		1	0.00	14	0	0	0	15.0	7	0	0	0	2	0	0		54	0
16	Chris Short C. Short	114	10/2/1965	PHI	@	NYM		1	0.00	18	0	0	0	15.0	9	0	0	0	3	0	0	1	56	0
17	Herb Pennock H. Pennock	114	7/4/1925	NYY	vs	PHA	W	1	0.00	5	1	1	0	15.0	4	0	0	0	0	0	0		47	0
18	Jeff Pfeffer J. Pfeffer	114	9/4/1917	BKN	vs	PHN		1	0.00	9	1	1	0	14.0	3	0	0	0	1	0	0		45	0
19	Russ Ford R. Ford	114	10/9/1914	BUF	@	PTF	W	1	0.00	3	1	1	0	16.0	5	0	0	0	1	0	0		55	0
20	Rube Marquard R. Marquard	113	7/17/1914	NYG	@	PTN	W	1	0.43	2	1	0	0	21.0	15	1	1	0	2	1	0		79	0
21	Gaylord Perry G. Perry	112	9/1/1967	SFG	@	CIN		1	0.00	12	0	0	0	16.0	10	0	0	0	2	1	0	1	59	0
22	Rob Gardner R. Gardner	112	10/2/1965	NYM	vs	PHI		1	0.00	7	0	0	0	15.0	5	0	0	0	2	0	0	0	53	0
23	Juan Marichal J. Marichal	112	7/2/1963	SFG	vs	MIL	W	1	0.00	10	1	1	0	16.0	8	0	0	0	4	0	0	0	59	0
24	Johnny Antonelli J. Antonelli	112	5/1/1955	NYG	vs	CIN	W	1	0.56	11	1	0	0	16.0	6	1	1	0	5	2	0	0	57	0
25	Les Mueller L. Mueller	112	7/21/1945	DET	@	PHA		1	0.00	6	0	0	0	19.2	13	0	1	0	5	0	0		74	0