Pitcher Don Wilson played 9 seasons for the Astros. He had 104 wins, 92 losses, an earned run average of 3.15, and 1,283 strikeouts. Wilson was selected to play in 1 All-Star Game.
| Season | TM | LG | W | L | ERA | G | GS | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | SO |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1966 | HOU | NL | 1 | 0 | 3.00 | 1 | 0 | 0 | 0 | 0 | 6.0 | 5 | 2 | 2 | 1 | 1 | 0 | 7 |
| 1967 | HOU | NL | 10 | 9 | 2.79 | 31 | 28 | 7 | 3 | 0 | 184.0 | 141 | 57 | 67 | 10 | 69 | 7 | 159 |
| 1968 | HOU | NL | 13 | 16 | 3.28 | 33 | 30 | 9 | 3 | 0 | 208.2 | 187 | 76 | 85 | 9 | 70 | 4 | 175 |
| 1969 | HOU | NL | 16 | 12 | 4.00 | 34 | 34 | 13 | 1 | 0 | 225.0 | 210 | 100 | 119 | 16 | 97 | 9 | 235 |
| 1970 | HOU | NL | 11 | 6 | 3.91 | 29 | 27 | 3 | 0 | 0 | 184.1 | 188 | 80 | 92 | 15 | 66 | 7 | 94 |
| 1971 | HOU | NL | 16 | 10 | 2.45 | 35 | 34 | 18 | 3 | 0 | 268.0 | 195 | 73 | 80 | 15 | 79 | 7 | 180 |
| 1972 | HOU | NL | 15 | 10 | 2.68 | 33 | 33 | 13 | 3 | 0 | 228.1 | 196 | 68 | 79 | 16 | 66 | 2 | 172 |
| 1973 | HOU | NL | 11 | 16 | 3.20 | 37 | 32 | 10 | 3 | 2 | 239.1 | 187 | 85 | 94 | 21 | 92 | 7 | 149 |
| 1974 | HOU | NL | 11 | 13 | 3.08 | 33 | 27 | 5 | 4 | 0 | 204.2 | 170 | 70 | 80 | 16 | 100 | 4 | 112 |
| Career | 104 | 92 | 3.15 | 266 | 245 | 78 | 20 | 2 | 1748.1 | 1,479 | 611 | 698 | 119 | 640 | 47 | 1,283 |