QXO (QXO) had the highest return between 2012 and 2017 by a large-cap US stock, returning 1,416,071.4%.

ASSET	YEARS	% RETURN
QXO (QXO)	2012-2017	1,416,071.43%
Genmab A-S (GMAB)	2012-2017	2,434.56%
Celsius (CELH)	2012-2017	2,400%
Netflix (NFLX)	2012-2017	1,811.95%
Alnylam Pharmaceuticals (ALNY)	2012-2017	1,425.21%
NVIDIA (NVDA)	2012-2017	1,359.4%
Texas Pacific Land Trust (TPL)	2012-2017	1,035.19%
Constellation Brands Inc Class A (STZ)	2012-2017	1,021.22%
Tesla (TSLA)	2012-2017	975.86%
Huazhu (HTHT)	2012-2017	945.15%
Builders FirstSource (BLDR)	2012-2017	937.62%
American Airlines (AAL)	2012-2017	934.47%
Insmed (INSM)	2012-2017	899.36%
Broadcom (AVGO)	2012-2017	864.39%
Align Technology (ALGN)	2012-2017	816.63%
Neurocrine Biosciences (NBIX)	2012-2017	787.76%
NetEase (NTES)	2012-2017	739.14%
Monolithic Power Systems (MPWR)	2012-2017	695.66%
Take-Two Interactive Software (TTWO)	2012-2017	693.78%
Huntington Ingalls Industries (HII)	2012-2017	684.97%
Southwest Airlines (LUV)	2012-2017	684.27%
EPAM Systems (EPAM)	2012-2017	681.31%
NXP Semiconductors (NXPI)	2012-2017	642.02%
XPO Logistics (XPO)	2012-2017	632.72%
Burlington Stores (BURL)	2012-2017	623.71%

Large-cap stocks are treated as having a market cap of $10B+.