American International (AIG) had the lowest return between 2001 and 2022 by a US stock in the S&P 500 (GSPC), returning -94.9%.

ASSET	YEARS	% RETURN
American International (AIG)	2001-2022	-94.9%
Coinbase Global (COIN)	2001-2022	-90.71%
Howmet Aerospace (HWM)	2001-2022	-86.66%
Citigroup (C)	2001-2022	-85.17%
Applovin (APP)	2001-2022	-84.96%
Robinhood Markets (HOOD)	2001-2022	-78.58%
GE Aerospace (GE)	2001-2022	-58.05%
Carnival (CCL)	2001-2022	-56.98%
DoorDash, Inc Class A Common Stock (DASH)	2001-2022	-52.14%
Norwegian Cruise Line (NCLH)	2001-2022	-51.24%
Marathon Petroleum (MPC)	2001-2022	-45.65%
Airbnb (ABNB)	2001-2022	-41.44%
Uber Technologies (UBER)	2001-2022	-41.12%
Palantir Technologies Inc Class A Common Stock (PLTR)	2001-2022	-35.8%
AES (AES)	2001-2022	-29.85%
Fox Corp Class B (FOX)	2001-2022	-22.05%
Fox Corp Class A (FOXA)	2001-2022	-15.66%
Invesco (IVZ)	2001-2022	-14.91%
Corning (GLW)	2001-2022	-13.66%
Ford Motor (F)	2001-2022	-7.56%
GE HealthCare Technologies (GEHC)	2001-2022	-7.33%
United Airlines (UAL)	2001-2022	-7.32%
Kinder Morgan (KMI)	2001-2022	-1.55%
Fifth Third Bancorp (FITB)	2001-2022	2%
International Paper (IP)	2001-2022	8.5%