Madrigal Pharmaceuticals (MDGL) had the highest return between 2016 and 2017 by a large-cap US stock, returning 694.7%.

ASSET	YEARS	% RETURN
Madrigal Pharmaceuticals (MDGL)	2016-2017	694.72%
Teck Resources Ltd Class B (TECK)	2016-2017	633.84%
NVIDIA (NVDA)	2016-2017	507.4%
EXACT Sciences (EXAS)	2016-2017	485.08%
Exelixis (EXEL)	2016-2017	452.73%
Huazhu (HTHT)	2016-2017	376.55%
Centrais Electricas Brasileiras (EBR)	2016-2017	335.21%
AXIA Energia (AXIA)	2016-2017	335.13%
Vale SA ADR (VALE)	2016-2017	305.43%
Leonardo DRS, Inc Common Stock (DRS)	2016-2017	305.26%
IAMGold (IAG)	2016-2017	299.32%
Advanced Micro Devices (AMD)	2016-2017	271.12%
Texas Pacific Land Trust (TPL)	2016-2017	256.81%
argenx NV ADR (ARGX)	2016-2017	252.74%
XPO Logistics (XPO)	2016-2017	252.13%
STMicroelectronics NV ADR (STM)	2016-2017	249.43%
ArcelorMittal SA ADR (MT)	2016-2017	248.9%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2016-2017	244.75%
Centrais Elétricas Brasileiras SA - Eletrobrás (EBR.B)	2016-2017	242.96%
Align Technology (ALGN)	2016-2017	241.88%
SPX (SPXC)	2016-2017	240.46%
BeiGene (ONC)	2016-2017	237.31%
Roku (ROKU)	2016-2017	228.14%
Take-Two Interactive Software (TTWO)	2016-2017	222.41%
Arista Networks (ANET)	2016-2017	202.61%

Large-cap stocks are treated as having a market cap of $10B+.