best performing biotech stocks in last 40 years with market cap above 10 billion

Amgen (AMGN) has had the highest return between October 4, 1985 and October 4, 2025 by a US stock in the Biotechnology Industry with a market cap of $10B+, returning 252,563.3%.

ASSET DATE % RETURN
Amgen (AMGN)
10/4/1985 - 10/4/2025
252,563.27%
Gilead Sciences (GILD)
10/4/1985 - 10/4/2025
29,791.25%
Vertex Pharmaceuticals (VRTX)
10/4/1985 - 10/4/2025
8,862.22%
Alnylam Pharmaceuticals (ALNY)
10/4/1985 - 10/4/2025
7,381.15%
United Therapeutics (UTHR)
10/4/1985 - 10/4/2025
6,612.05%
Biogen (BIIB)
10/4/1985 - 10/4/2025
5,229.33%
Incyte (INCY)
10/4/1985 - 10/4/2025
4,532%
argenx NV ADR (ARGX)
10/4/1985 - 10/4/2025
4,369.27%
Regeneron Pharmaceuticals (REGN)
10/4/1985 - 10/4/2025
2,638.96%
BeiGene (ONC)
10/4/1985 - 10/4/2025
1,086.99%
Neurocrine Biosciences (NBIX)
10/4/1985 - 10/4/2025
996.24%
AbbVie (ABBV)
10/4/1985 - 10/4/2025
954.88%
Ascendis Pharma A-S (ASND)
10/4/1985 - 10/4/2025
849.07%
Genmab A-S (GMAB)
10/4/1985 - 10/4/2025
789.71%
Natera (NTRA)
10/4/1985 - 10/4/2025
657.24%
Ionis Pharmaceuticals (IONS)
10/4/1985 - 10/4/2025
597.61%
BioNTech SE (BNTX)
10/4/1985 - 10/4/2025
539.33%
EXACT Sciences (EXAS)
10/4/1985 - 10/4/2025
284.54%
Biomarin Pharmaceutical (BMRN)
10/4/1985 - 10/4/2025
269.53%
Exelixis (EXEL)
10/4/1985 - 10/4/2025
122.72%
Summit Therapeutics (SMMT)
10/4/1985 - 10/4/2025
116.46%
BridgeBio Pharma (BBIO)
10/4/1985 - 10/4/2025
72.69%
Roivant Sciences (ROIV)
10/4/1985 - 10/4/2025
54%
Moderna (MRNA)
10/4/1985 - 10/4/2025
29.5%
Madrigal Pharmaceuticals (MDGL)
10/4/1985 - 10/4/2025
26.57%