QXO (QXO) had the highest return between 2002 and 2012 by a large-cap US stock, returning 115,105%.

ASSET	YEARS	% RETURN
QXO (QXO)	2002-2012	115,105%
NetEase (NTES)	2002-2012	22,581.29%
Monster Beverage (MNST)	2002-2012	19,824.66%
Grupo Cibest (CIB)	2002-2012	6,233.86%
Apple (AAPL)	2002-2012	4,769.1%
Cheniere Energy (LNG)	2002-2012	3,854.05%
Southern Copper (SCCO)	2002-2012	3,845.58%
Ambev SA ADR (ABEV)	2002-2012	3,667.25%
Clean Harbors (CLH)	2002-2012	3,184.18%
Banco Bradesco SA ADR (BBD)	2002-2012	2,833.15%
Deckers Outdoor (DECK)	2002-2012	2,632.78%
Intuitive Surgical (ISRG)	2002-2012	2,401.74%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2002-2012	2,387.58%
Alamos Gold (AGI)	2002-2012	2,206.91%
Amazon (AMZN)	2002-2012	2,193.98%
Credicorp (BAP)	2002-2012	2,173.52%
Cognizant Technology Solutions Corp Class A (CTSH)	2002-2012	2,066.89%
Chunghwa Telecom (CHT)	2002-2012	2,016.77%
Tractor Supply (TSCO)	2002-2012	2,012.82%
Old Dominion Freight Line (ODFL)	2002-2012	1,852.98%
Vale SA ADR (VALE)	2002-2012	1,797.15%
Booking (BKNG)	2002-2012	1,670.52%
Royal Gold (RGLD)	2002-2012	1,628.41%
Tenaris SA ADR (TS)	2002-2012	1,532.72%
Flutter Entertainment (FLUT)	2002-2012	1,517.97%

Large-cap stocks are treated as having a market cap of $10B+.