Booking (BKNG) had the highest return between 1998 and 2008 by a large-cap US stock, returning 24,154,666.7%.

ASSET	YEARS	% RETURN
Booking (BKNG)	1998-2008	24,154,666.67%
AngloGold Ashanti (AU)	1998-2008	11,452,150%
Monster Beverage (MNST)	1998-2008	14,606.32%
Cognizant Technology Solutions Corp Class A (CTSH)	1998-2008	4,234.38%
Clean Harbors (CLH)	1998-2008	3,659.18%
Ovintiv (OVV)	1998-2008	2,687.31%
Apple (AAPL)	1998-2008	2,404.7%
Gilead Sciences (GILD)	1998-2008	2,039.31%
NVR (NVR)	1998-2008	1,985.71%
Sterling Construction (STRL)	1998-2008	1,880.97%
Banco Bradesco SA ADR (BBD)	1998-2008	1,374.7%
Laboratory Corporation of America (LH)	1998-2008	1,372.52%
Altria (MO)	1998-2008	1,319.97%
Johnson Controls International (JCI)	1998-2008	1,234.46%
Rogers Communications (RCI)	1998-2008	1,224.19%
Southern Copper (SCCO)	1998-2008	1,219.27%
Quest Diagnostics (DGX)	1998-2008	1,176.64%
Qualcomm (QCOM)	1998-2008	1,141.97%
Royal Gold (RGLD)	1998-2008	1,126.59%
CH Robinson Worldwide (CHRW)	1998-2008	1,021.53%
Chunghwa Telecom (CHT)	1998-2008	996.6%
ResMed (RMD)	1998-2008	961.36%
Elbit Systems (ESLT)	1998-2008	960.22%
BlackRock (BLK)	1998-2008	941.38%
Deckers Outdoor (DECK)	1998-2008	930.47%

Large-cap stocks are treated as having a market cap of $10B+.