NVIDIA (NVDA) had the highest return between 2013 and 2017 by a large-cap US stock, returning 1,551.6%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2013-2017	1,551.61%
Netflix (NFLX)	2013-2017	1,311.37%
Genmab A-S (GMAB)	2013-2017	1,084%
Neurocrine Biosciences (NBIX)	2013-2017	910.29%
Take-Two Interactive Software (TTWO)	2013-2017	878.43%
Tesla (TSLA)	2013-2017	789.59%
NetEase (NTES)	2013-2017	773.44%
Huazhu (HTHT)	2013-2017	762.86%
Broadcom (AVGO)	2013-2017	761.52%
Texas Pacific Land (TPL)	2013-2017	736.66%
Align Technology (ALGN)	2013-2017	677.7%
Burlington Stores (BURL)	2013-2017	623.71%
Electronic Arts (EA)	2013-2017	611.31%
Alnylam Pharmaceuticals (ALNY)	2013-2017	570.45%
Best Buy (BBY)	2013-2017	557.9%
Cognex (CGNX)	2013-2017	557.18%
Constellation Brands Inc Class A (STZ)	2013-2017	553.71%
Southwest Airlines (LUV)	2013-2017	551.92%
Diamondback Energy (FANG)	2013-2017	548.77%
Exelixis (EXEL)	2013-2017	546.81%
Facebook (META)	2013-2017	543.07%
Micron Technology (MU)	2013-2017	523.03%
Ubiquiti Networks (UI)	2013-2017	471.68%
Huntington Ingalls Industries (HII)	2013-2017	470.46%
Incyte (INCY)	2013-2017	466.45%

Large-cap stocks are treated as having a market cap of $10B+.