Ovintiv (OVV) had the highest return between 2001 and 2008 by a large-cap US stock, returning 82,345,000%.

ASSET	YEARS	% RETURN
Ovintiv (OVV)	2001-2008	82,345,000%
InterContinental Hotels Group PLC ADR (IHG)	2001-2008	5,519,600%
Natwest (NWG)	2001-2008	1,589,066.67%
National Grid PLC ADR (NGG)	2001-2008	824,847.62%
Monster Beverage (MNST)	2001-2008	6,938.29%
Clean Harbors (CLH)	2001-2008	3,461.64%
NetEase (NTES)	2001-2008	2,728.7%
Royal Gold (RGLD)	2001-2008	1,693.67%
Tractor Supply (TSCO)	2001-2008	1,600.46%
Deckers Outdoor (DECK)	2001-2008	1,497.26%
Bancolombia SA ADR (CIB)	2001-2008	1,440.81%
Southern Copper (SCCO)	2001-2008	1,168.78%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2001-2008	1,089.54%
ArcelorMittal SA ADR (MT)	2001-2008	1,088.37%
Apple (AAPL)	2001-2008	1,047.42%
Chunghwa Telecom (CHT)	2001-2008	996.6%
Kinross Gold (KGC)	2001-2008	996.23%
Elbit Systems (ESLT)	2001-2008	969%
Credicorp (BAP)	2001-2008	954.59%
Hologic (HOLX)	2001-2008	895.81%
Gilead Sciences (GILD)	2001-2008	879.93%
Old Dominion Freight Line (ODFL)	2001-2008	860.46%
Vale SA ADR (VALE)	2001-2008	834.5%
Axon Enterprise (AXON)	2001-2008	805.19%
Booking (BKNG)	2001-2008	792.75%

Large-cap stocks are treated as having a market cap of $10B+.