National Grid PLC ADR (NGG) had the highest return between 2003 and 2009 by a large-cap US stock, returning 1,234,075%.

ASSET	YEARS	% RETURN
National Grid PLC ADR (NGG)	2003-2009	1,234,075%
Monster Beverage (MNST)	2003-2009	7,189.29%
Banco Bradesco SA ADR (BBD)	2003-2009	4,632.2%
Deckers Outdoor (DECK)	2003-2009	2,972.92%
Apple (AAPL)	2003-2009	2,834.23%
Bancolombia SA ADR (CIB)	2003-2009	2,516.26%
Intuitive Surgical (ISRG)	2003-2009	2,367.03%
ArcelorMittal SA ADR (MT)	2003-2009	2,329.99%
Booking (BKNG)	2003-2009	2,147%
Southern Copper (SCCO)	2003-2009	2,128.23%
Vale SA ADR (VALE)	2003-2009	1,973.69%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2003-2009	1,861.73%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2003-2009	1,764.25%
Illumina (ILMN)	2003-2009	1,699.37%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2003-2009	1,649.9%
Ambev SA ADR (ABEV)	2003-2009	1,623.32%
Itau Unibanco Banco (ITUB)	2003-2009	1,619.19%
Williams Companies (WMB)	2003-2009	1,500.04%
Alamos Gold (AGI)	2003-2009	1,434.52%
Akamai Technologies (AKAM)	2003-2009	1,307.78%
Chunghwa Telecom (CHT)	2003-2009	1,286.52%
Tenaris SA ADR (TS)	2003-2009	1,241.66%
Axon Enterprise (AXON)	2003-2009	1,197.78%
NetEase (NTES)	2003-2009	1,184.88%
Trip Group Ltd ADR (TCOM)	2003-2009	1,118.93%

Large-cap stocks are treated as having a market cap of $10B+.