QXO (QXO) had the highest return between 2012 and 2014 by a large-cap US stock, returning 14,784,550%.

ASSET	YEARS	% RETURN
QXO (QXO)	2012-2014	14,784,550%
Alnylam Pharmaceuticals (ALNY)	2012-2014	1,064.47%
American Airlines (AAL)	2012-2014	936.57%
Genmab A-S (GMAB)	2012-2014	796.02%
Ionis Pharmaceuticals (IONS)	2012-2014	740%
Cheniere Energy (LNG)	2012-2014	691.9%
Tesla (TSLA)	2012-2014	668.53%
Regeneron Pharmaceuticals (REGN)	2012-2014	625.98%
Saia (SAIA)	2012-2014	542.23%
Delta Air Lines (DAL)	2012-2014	505.67%
Illumina (ILMN)	2012-2014	495.42%
DexCom (DXCM)	2012-2014	478.26%
Micron Technology (MU)	2012-2014	427.26%
Axon Enterprise (AXON)	2012-2014	405.34%
Corpay (CPAY)	2012-2014	396.2%
Insmed (INSM)	2012-2014	395.83%
Southwest Airlines (LUV)	2012-2014	395.1%
Globalstar, Inc Common Stock (GSAT)	2012-2014	391.07%
Netflix (NFLX)	2012-2014	386.07%
Incyte (INCY)	2012-2014	385.78%
NXP Semiconductors (NXPI)	2012-2014	384.15%
Constellation Brands Inc Class A (STZ)	2012-2014	368.37%
Gilead Sciences (GILD)	2012-2014	354.71%
Seagate Technology (STX)	2012-2014	343.19%
Skyworks Solutions (SWKS)	2012-2014	333.22%

Large-cap stocks are treated as having a market cap of $10B+.