Celsius (CELH) had the highest return between 2020 and 2022 by a large-cap US stock, returning 2,054%.

ASSET	YEARS	% RETURN
Celsius (CELH)	2020-2022	2,054.04%
GameStop (GME)	2020-2022	1,102.61%
Antero Resources (AR)	2020-2022	976.04%
Moderna (MRNA)	2020-2022	817.83%
Tesla (TSLA)	2020-2022	335.27%
BioNTech SE (BNTX)	2020-2022	320.2%
Futu (FUTU)	2020-2022	288.25%
Quanta Services (PWR)	2020-2022	250.23%
Super Micro Computer (SMCI)	2020-2022	244.23%
Carrier Global (CARR)	2020-2022	243.75%
Texas Pacific Land Trust (TPL)	2020-2022	219.32%
EQT (EQT)	2020-2022	215.2%
United Therapeutics (UTHR)	2020-2022	214.76%
Steel Dynamics (STLD)	2020-2022	205.49%
Freeport-McMoran Copper & Gold (FCX)	2020-2022	192.58%
Eli Lilly and (LLY)	2020-2022	191.36%
BJs Wholesale Club (BJ)	2020-2022	187.15%
Devon Energy (DVN)	2020-2022	186.01%
United Microelectronics (UMC)	2020-2022	181.57%
McKesson (MCK)	2020-2022	176.65%
Dick’s Sporting Goods (DKS)	2020-2022	171.15%
Summit Therapeutics (SMMT)	2020-2022	165.63%
First Solar (FSLR)	2020-2022	165.59%
Cloudflare (NET)	2020-2022	162.24%
Kinsale Capital (KNSL)	2020-2022	158.29%

Large-cap stocks are treated as having a market cap of $10B+.