Monster Beverage (MNST) had the highest return between 2001 and 2009 by a large-cap US stock, returning 7,960.5%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2001-2009	7,960.45%
NetEase (NTES)	2001-2009	4,714.98%
Banco Bradesco SA ADR (BBD)	2001-2009	4,120.08%
Clean Harbors (CLH)	2001-2009	3,246.62%
Bancolombia SA ADR (CIB)	2001-2009	3,013.58%
Apple (AAPL)	2001-2009	2,733.65%
Southern Copper (SCCO)	2001-2009	2,550.07%
Booking (BKNG)	2001-2009	2,547.52%
Tractor Supply (TSCO)	2001-2009	2,392.9%
ArcelorMittal SA ADR (MT)	2001-2009	2,317.87%
Vale SA ADR (VALE)	2001-2009	2,310.47%
Deckers Outdoor (DECK)	2001-2009	1,934.23%
Intuitive Surgical (ISRG)	2001-2009	1,767.32%
Royal Gold (RGLD)	2001-2009	1,628.88%
Western Digital (WDC)	2001-2009	1,622.99%
Credicorp (BAP)	2001-2009	1,579.27%
Tenaris SA ADR (TS)	2001-2009	1,470.66%
ANSYS (ANSS)	2001-2009	1,446.62%
Elbit Systems (ESLT)	2001-2009	1,446.52%
Alamos Gold (AGI)	2001-2009	1,434.57%
Cognizant Technology Solutions Corp Class A (CTSH)	2001-2009	1,391.53%
Telkom Indonesia (Persero) Tbk PT ADR Rep 100 B (TLK)	2001-2009	1,307.97%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2001-2009	1,259.61%
BHP (BHP)	2001-2009	1,182.05%
CarMax (KMX)	2001-2009	1,131.71%

Large-cap stocks are treated as having a market cap of $10B+.