Nutanix (NTNX) had the highest return in September 2016 by a large-cap US stock, returning 39.6%.

ASSET	MONTH	% RETURN
Nutanix (NTNX)	September 2016	39.62%
Summit Therapeutics (SMMT)	September 2016	37.33%
Texas Pacific Land Trust (TPL)	September 2016	35.97%
Liberty Media Corporation Series A Liberty Formula One Common Stock (FWONA)	September 2016	34.13%
Liberty Media Corporation Series C Liberty Formula One Common Stock (FWONK)	September 2016	32.61%
Western Digital (WDC)	September 2016	26.36%
Permian Resources (PR)	September 2016	25.6%
Ionis Pharmaceuticals (IONS)	September 2016	23.28%
Sterling Construction (STRL)	September 2016	20.37%
Twilio (TWLO)	September 2016	20.05%
Palo Alto Networks (PANW)	September 2016	19.55%
Lumentum (LITE)	September 2016	18.53%
QXO (QXO)	September 2016	18.43%
Western Midstream Partners (WES)	September 2016	17.73%
Alamos Gold (AGI)	September 2016	17.65%
Seagate Technology (STX)	September 2016	16.2%
BHP (BHP)	September 2016	15.77%
Incyte (INCY)	September 2016	15.54%
NXP Semiconductors (NXPI)	September 2016	15.42%
Exelixis (EXEL)	September 2016	14.91%
Fabrinet (FN)	September 2016	14.83%
Pure Storage (PSTG)	September 2016	14.83%
Smurfit WestRock (SW)	September 2016	14.63%
Coherent (COHR)	September 2016	14.55%
ON Semiconductor (ON)	September 2016	14.18%

Large-cap stocks are treated as having a market cap of $10B+.