Wave Life Sciences (WVE) had the highest return in December 2025 by a US stock with a market cap of $2B+, returning 123.7%.

ASSET	MONTH	% RETURN
Wave Life Sciences (WVE)	December 2025	123.68%
Structure Therapeutics Inc American Depositary Shares (GPCR)	December 2025	97.25%
Hycroft Mining (HYMC)	December 2025	91.93%
Regencell Bioscience (RGC)	December 2025	82.45%
Intuitive Machines (LUNR)	December 2025	76.22%
Planet Labs PBC (PL)	December 2025	70%
Rocket Lab USA (RKLB)	December 2025	69.53%
Andersen (ANDG)	December 2025	62.06%
Digitalbridge (DBRG)	December 2025	61.41%
EchoStar (SATS)	December 2025	52.52%
Praxis Precision Medicines (PRAX)	December 2025	52.37%
Vera Therapeutics (VERA)	December 2025	51.75%
Terns Pharmaceuticals (TERN)	December 2025	44.8%
Amicus Therapeutics (FOLD)	December 2025	43.55%
Redwire (RDW)	December 2025	43.13%
Photronics (PLAB)	December 2025	41.28%
EverCommerce (EVCM)	December 2025	40.49%
Confluent (CFLT)	December 2025	38.46%
Applied Opt (AAOI)	December 2025	35.22%
Ast Spacemobile (ASTS)	December 2025	33.63%
Victoria's Secret (VSCO)	December 2025	33.23%
Century Aluminum (CENX)	December 2025	31.21%
Alumis (ALMS)	December 2025	30.48%
American Eagle Outfitters (AEO)	December 2025	29.71%
Abercrombie & Fitch (ANF)	December 2025	29.54%