Amerant Bancorp (AMTB) had the highest return between 2018 and 2022 by a US stock, returning 8,533,633.3%.

ASSET	YEARS	% RETURN
Amerant Bancorp (AMTB)	2018-2022	8,533,633.33%
BioNexus Gene Lab Corp Common stock (BGLC)	2018-2022	2,780,387.8%
KULR Technology (KULR)	2018-2022	2,399,900%
Weatherford International (WFRD)	2018-2022	1,921,376.92%
Diversified Energy (DEC)	2018-2022	579,200%
Avalon GloboCare (ALBT)	2018-2022	487,400%
GreenPower Motor (GP)	2018-2022	432,400%
Immatics (IMTX)	2018-2022	174,100%
MDxHealth SA ADR (MDXH)	2018-2022	169,387.18%
MicroCloud Hologram (HOLO)	2018-2022	131,516.22%
Integra Resources (ITRG)	2018-2022	105,400%
Castellum (CTM)	2018-2022	40,545.16%
Applied Digital (APLD)	2018-2022	30,566.67%
FitLife Brands, Inc Common Stock (FTLF)	2018-2022	25,379.23%
Alarum Technologies (ALAR)	2018-2022	19,412.2%
GeoVax Labs (GOVX)	2018-2022	19,146.44%
Kaival Brands Innovations (KAVL)	2018-2022	14,858.33%
Bone Biologics (BBLG)	2018-2022	13,199.91%
Enphase Energy (ENPH)	2018-2022	10,986.19%
Delcath Systems (DCTH)	2018-2022	6,903.89%
Xpel (XPEL)	2018-2022	4,100%
Zivo Bioscience (ZIVO)	2018-2022	2,817.15%
Graf Industrial Corp Warrants (each warrant exercisable for one-half of one share of common stock each at an exercise price of $1150 per share) (GRAF.WT)	2018-2022	2,208.78%
374Water Inc Common Stock (SCWO)	2018-2022	2,100%
Celsius (CELH)	2018-2022	1,855.68%