GeoVax Labs (GOVX) had the highest return between 2008 and 2011 by a US stock, returning 5,263,157,794.2%.

ASSET	YEARS	% RETURN
GeoVax Labs (GOVX)	2008-2011	5,263,157,794.21%
Future Fintech (FTFT)	2008-2011	19,076,823.08%
Castellum (CTM)	2008-2011	6,521,639.13%
Sequans Communications (SQNS)	2008-2011	3,349,297.59%
Ridgetech (RDGT)	2008-2011	1,865,196.16%
Metalla Royalty & Streaming (MTA)	2008-2011	185,785.71%
Versus Systems Inc. (VS)	2008-2011	120,706.4%
Pioneer Power Solutions (PPSI)	2008-2011	15,915.77%
Arena (AREN)	2008-2011	11,279.31%
Cocrystal Pharma (COCP)	2008-2011	4,806.67%
Mitek Systems (MITK)	2008-2011	1,807.89%
LifeMD (LFMD)	2008-2011	1,566.67%
Oxley Bridge Acquisition Limited Class A Ordinary Shares (OBA)	2008-2011	1,472.96%
eGain (EGAN)	2008-2011	1,435.56%
Lineage Cell Therapeutics (LCTX)	2008-2011	1,317.2%
Brand House Collective (TBHC)	2008-2011	1,299.98%
VerifyMe (VRME)	2008-2011	1,233.33%
Nexentis Technologies (NXTS)	2008-2011	1,150%
Mesoblast (MESO)	2008-2011	979.72%
Clearfield (CLFD)	2008-2011	863.29%
Altisource Portfolio Solutions (ASPS)	2008-2011	796.07%
Virtus Investment Partners (VRTS)	2008-2011	744.56%
Amneal Pharmaceuticals, Inc Class A Common Stock (AMRX)	2008-2011	706.8%
VirTra (VTSI)	2008-2011	690%
BTCS (BTCS)	2008-2011	674%