XORTX Therapeutics (XRTX) had the highest return between 2020 and 2022 by a US stock, returning 959,548.1%.

ASSET	YEARS	% RETURN
XORTX Therapeutics (XRTX)	2020-2022	959,548.09%
authID (AUID)	2020-2022	661,614.29%
MDxHealth SA ADR (MDXH)	2020-2022	600,809.09%
Next Technology (NXTT)	2020-2022	358,304.56%
Heart Test Laboratories Inc Common Stock (HSCS)	2020-2022	246,958.82%
Connexa Sports Technologies (YYAI)	2020-2022	187,100%
Zhongchao (ZCMD)	2020-2022	157,567.24%
Applied Digital (APLD)	2020-2022	153,233.33%
Integra Resources (ITRG)	2020-2022	105,400%
Nauticus Robotics (KITT)	2020-2022	99,224.58%
Sunshine Biopharma (SBFM)	2020-2022	79,900%
Digi Power X (DGXX)	2020-2022	39,900%
Guardforce AI (GFAI)	2020-2022	24,323.08%
Castellum (CTM)	2020-2022	22,809.09%
Clearmind Medicine Inc Common Shares (CMND)	2020-2022	18,021.78%
COSCIENS Biopharma (CSCI)	2020-2022	8,052.54%
Bone Biologics (BBLG)	2020-2022	7,460%
Chord Energy (CHRD)	2020-2022	5,357.22%
Ainos (AIMD)	2020-2022	5,066.67%
CPI Card (PMTS)	2020-2022	3,908.89%
374Water Inc Common Stock (SCWO)	2020-2022	3,077.78%
Sigma Lithium Resources (SGML)	2020-2022	2,070.77%
Celsius (CELH)	2020-2022	2,054.04%
Empire Petroleum (EP)	2020-2022	1,950%
Celldex Therapeutics (CLDX)	2020-2022	1,889.73%