best performing stocks in last 4 years with market cap above 50 billion

Vistra Energy (VST) has had the highest return between September 28, 2021 and September 28, 2025 by a US stock with a market cap of $50B+, returning 1,217.3%.

ASSET DATE % RETURN
Vistra Energy (VST)
9/28/2021 - 9/28/2025
1,217.35%
Applovin (APP)
9/28/2021 - 9/28/2025
800.59%
Constellation Energy (CEG)
9/28/2021 - 9/28/2025
800.5%
NVIDIA (NVDA)
9/28/2021 - 9/28/2025
741.61%
Broadcom (AVGO)
9/28/2021 - 9/28/2025
629.84%
Palantir Technologies Inc Class A Common Stock (PLTR)
9/28/2021 - 9/28/2025
557.18%
Arista Networks (ANET)
9/28/2021 - 9/28/2025
544.69%
Howmet Aerospace  (HWM)
9/28/2021 - 9/28/2025
488.83%
Vertiv (VRT)
9/28/2021 - 9/28/2025
479.87%
MicroStrategy (MSTR)
9/28/2021 - 9/28/2025
428.08%
GE Vernova LLC (GEV)
9/28/2021 - 9/28/2025
427.26%
GE Aerospace (GE)
9/28/2021 - 9/28/2025
357.89%
Interactive Brokers (IBKR)
9/28/2021 - 9/28/2025
311.84%
Axon Enterprise (AXON)
9/28/2021 - 9/28/2025
298.49%
McKesson (MCK)
9/28/2021 - 9/28/2025
281.06%
Banco Bilbao Viscaya Argentaria SA ADR (BBVA)
9/28/2021 - 9/28/2025
272.4%
Agnico Eagle Mines (AEM)
9/28/2021 - 9/28/2025
267.77%
Petroleo Brasileiro Petrobras SA ADR (PBR)
9/28/2021 - 9/28/2025
266.45%
Royal Caribbean Cruises (RCL)
9/28/2021 - 9/28/2025
260.02%
Petróleo Brasileiro SA - Petrobras (PBR.A)
9/28/2021 - 9/28/2025
257.82%
Quanta Services (PWR)
9/28/2021 - 9/28/2025
252.42%
Marathon Petroleum (MPC)
9/28/2021 - 9/28/2025
242.19%
HSBC Holdings PLC ADR (HSBC)
9/28/2021 - 9/28/2025
234.29%
Amphenol (APH)
9/28/2021 - 9/28/2025
232.93%
Eli Lilly and (LLY)
9/28/2021 - 9/28/2025
232.75%