Regencell Bioscience (RGC) has had the highest return this year by a US stock in the Nasdaq Composite (IXIC), returning 13,941.9%.

ASSET	YEAR	% RETURN
Regencell Bioscience (RGC)	2025	13,941.92%
QMMM Holdings Limited Ordinary Shares (QMMM)	2025	9,155.81%
Diginex Limited Ordinary Shares (DGNX)	2025	3,736.62%
DeFi Development (DFDV)	2025	2,135.1%
WW International, Inc Common Stock (WW)	2025	2,124.43%
Abivax SA American Depositary Shares (ABVX)	2025	1,220.58%
Oncology Institute (TOI)	2025	1,210.46%
FiEE (FIEE)	2025	1,078.94%
Abits (ABTS)	2025	957.99%
Lizhi (SOGP)	2025	890.59%
Above Food Ingredients Inc Common Stock (ABVE)	2025	820%
Nanobiotix (NBTX)	2025	793.57%
Global Interactive Technologies (GITS)	2025	763.07%
TMC the metals (TMC)	2025	742.98%
Nova Lifestyle I (NVFY)	2025	723%
Epsium Enterprise Limited Ordinary Shares (EPSM)	2025	669.64%
Airnet Technology (ANTE)	2025	627.88%
I-Mab (IMAB)	2025	621.18%
Rich Sparkle Holdings Limited Ordinary Shares (ANPA)	2025	608.61%
mF International Limited Ordinary Shares (MFI)	2025	602.05%
Dominari (DOMH)	2025	567.92%
IREN (IREN)	2025	559.36%
Palvella Therapeutics (PVLA)	2025	557.28%
Better Home & Finance (BETR)	2025	553.96%
ThredUp (TDUP)	2025	551.39%