Sharplink Gaming (SBET) had the highest return in May 2025 by a US stock, returning 2,267.3%.

ASSET	MONTH	% RETURN
Sharplink Gaming (SBET)	May 2025	2,267.28%
Regencell Bioscience (RGC)	May 2025	1,494.29%
Strive Asset Management (ASST)	May 2025	1,082.52%
Kindly (NAKA)	May 2025	1,070.98%
NLS Pharmaceutics (NLSPW)	May 2025	866.67%
Next Technology (NXTT)	May 2025	516.13%
FiEE (FIEE)	May 2025	470.59%
Streamex (STEX)	May 2025	438.46%
American Bitcoin (ABTC)	May 2025	415.02%
Hyperscale Data (GPUS)	May 2025	291.24%
Roboai (AIIO)	May 2025	283.46%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	May 2025	281.25%
Spero Therapeutics (SPRO)	May 2025	273.13%
Im Cannabis (IMCC)	May 2025	258.38%
CytomX Therapeutics (CTMX)	May 2025	258.11%
DDC Enterprise (DDC)	May 2025	226.36%
Signing Day Sports (SGN)	May 2025	222.03%
Marwynn Holdings, Inc Common stock (MWYN)	May 2025	201.82%
Imunon (IMNN)	May 2025	200%
SG Blocks (SGBX)	May 2025	189.47%
Globavend Holdings Limited Ordinary Shares (GVH)	May 2025	171.29%
LZ Technology Holdings Limited Class B Ordinary Shares (LZMH)	May 2025	169.31%
Navitas Semiconductor (NVTS)	May 2025	162.89%
Starz Entertainment LLC (STRZ)	May 2025	162%
Aeva Technologies, Inc Common Stock (AEVA)	May 2025	155.88%