Olema Pharmaceuticals (OLMA) had the highest return last month by a US stock with a market cap of $300M+, returning 214.7%.

ASSET	MONTH	% RETURN
Olema Pharmaceuticals (OLMA)	November 2025	214.67%
PACS (PACS)	November 2025	175.89%
Cogent Biosciences (COGT)	November 2025	147.51%
Forge Global (FRGE)	November 2025	104.14%
Cidara Therapeutics (CDTX)	November 2025	103.27%
Relmada Therapeutics (RLMD)	November 2025	103.15%
Terns Pharmaceuticals (TERN)	November 2025	100.07%
Innventure (INV)	November 2025	97.59%
Falcon's Beyond Global, Inc Class A Common Stock (FBYD)	November 2025	85.81%
Ironwood Pharmaceuticals (IRWD)	November 2025	78.57%
E W Scripps Co Class A (SSP)	November 2025	75.52%
Babcock & Wilcox Enterprises (BW)	November 2025	73.61%
Inspire Medical Systems (INSP)	November 2025	72.65%
Sigma Lithium Resources (SGML)	November 2025	69.44%
Neuropace (NPCE)	November 2025	65.59%
Sight Sciences (SGHT)	November 2025	64.57%
Hotel101 Global Holdings Corp Class A Ordinary Shares (HBNB)	November 2025	63.33%
Semrush (SEMR)	November 2025	63.17%
Haemonetics (HAE)	November 2025	63.03%
Alumis (ALMS)	November 2025	62.85%
TryHard Holdings Limited Ordinary Shares (THH)	November 2025	61.93%
Tactile Systems Technology (TCMD)	November 2025	61.09%
Rigel Pharmaceuticals (RIGL)	November 2025	59.88%
McGraw Hill (MH)	November 2025	59.11%
Herbalife Nutrition (HLF)	November 2025	57.16%