INVO Fertility (IVF) had the highest return in Q4 2020 by a US stock, returning 304,747.6%.

ASSET	QUARTER	% RETURN
INVO Fertility (IVF)	Q4 2020	304,747.64%
COSCIENS Biopharma (CSCI)	Q4 2020	4,697.32%
Ascent Solar Technologies, Inc Common Stock (ASTI)	Q4 2020	3,900%
Osisko Development (ODV)	Q4 2020	1,566.67%
urban-gro (UGRO)	Q4 2020	1,512.9%
DeFi Technologies (DEFT)	Q4 2020	920%
Creative Medical Technology (CELZ)	Q4 2020	866.67%
American Battery Technology Company Common Stock (ABAT)	Q4 2020	865.52%
Bitfarms (BITF)	Q4 2020	691.67%
Greenwich Lifesciences (GLSI)	Q4 2020	667.79%
Performance Shipping (PSHG)	Q4 2020	663.87%
Natuzzi SpA (NTZ)	Q4 2020	633.92%
Ondas (ONDS)	Q4 2020	599.77%
Curis (CRIS)	Q4 2020	594.07%
Kaixin Auto (KXIN)	Q4 2020	563.7%
HIVE Blockchain Technologies (HIVE)	Q4 2020	540.68%
Riot Blockchain (RIOT)	Q4 2020	526.94%
Ocugen (OCGN)	Q4 2020	496.09%
Beam Global (BEEM)	Q4 2020	486.95%
Ryvyl (RVYL)	Q4 2020	453.3%
Emeren (SOL)	Q4 2020	446.89%
Mega Matrix (MPU)	Q4 2020	445.61%
Bit Digital (BTBT)	Q4 2020	433.09%
FuelCell Energy (FCEL)	Q4 2020	410.05%
Quantumscape (QS)	Q4 2020	402.68%