AngloGold Ashanti (AU) has had the highest return this year by a large-cap US stock, returning 73.1%.

ASSET	YEAR	% RETURN
AngloGold Ashanti (AU)	2025	73.07%
Xpeng (XPEV)	2025	70.79%
Palantir Technologies Inc Class A Common Stock (PLTR)	2025	63.1%
Banco Santander SA ADR (SAN)	2025	62.26%
Bancolombia SA ADR (CIB)	2025	58.48%
Gold Fields Ltd ADR (GFI)	2025	56.65%
Deutsche Bank (DB)	2025	55.81%
Summit Therapeutics (SMMT)	2025	55.26%
Elbit Systems (ESLT)	2025	55.13%
CVS Health (CVS)	2025	53.01%
Banco Bilbao Viscaya Argentaria SA ADR (BBVA)	2025	52.46%
Kinross Gold (KGC)	2025	50.41%
Alibaba (BABA)	2025	49.02%
Duolingo (DUOL)	2025	48.62%
Itau Unibanco Banco (ITUB)	2025	46.93%
Lloyds Banking Group PLC ADR (LYG)	2025	43.04%
Spotify Technology (SPOT)	2025	42.93%
Centrais Electricas Brasileiras (EBR)	2025	42.72%
Philip Morris International (PM)	2025	42.05%
Wheaton Precious Metals (WPM)	2025	41.51%
Okta (OKTA)	2025	41.13%
Banco De Chile (BCH)	2025	40.64%
Companhia de Saneamento Basico do Estado de Sao Paulo SABESP ADR (SBS)	2025	40.58%
Agnico Eagle Mines (AEM)	2025	40.54%
Banco Santander Brasil SA ADR (BSBR)	2025	40.22%

Large-cap stocks are treated as having a market cap of $10B+.