Howmet Aerospace (HWM) had the lowest return between 2013 and 2016 by a large-cap US stock, returning -95.3%.

ASSET	YEARS	% RETURN
Howmet Aerospace (HWM)	2013-2016	-95.34%
Ecopetrol SA ADR (EC)	2013-2016	-81.94%
Freedom (FRHC)	2013-2016	-72.5%
Gold Fields Ltd ADR (GFI)	2013-2016	-71.21%
Kinross Gold (KGC)	2013-2016	-68.46%
AngloGold Ashanti (AU)	2013-2016	-66.58%
Alamos Gold (AGI)	2013-2016	-60.28%
Vale SA ADR (VALE)	2013-2016	-59.26%
ArcelorMittal SA ADR (MT)	2013-2016	-57.68%
Freeport-McMoran Copper & Gold (FCX)	2013-2016	-56.67%
Deutsche Bank (DB)	2013-2016	-55.57%
Tenet Healthcare (THC)	2013-2016	-55.26%
Coca-Cola Femsa SAB de CV ADR (KOF)	2013-2016	-53.96%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2013-2016	-50.49%
Cenovus Energy (CVE)	2013-2016	-49.97%
Natwest (NWG)	2013-2016	-49.54%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2013-2016	-48.42%
Natera (NTRA)	2013-2016	-47.01%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2013-2016	-46.49%
Sprouts Farmers Market LLC (SFM)	2013-2016	-45.94%
Wheaton Precious Metals (WPM)	2013-2016	-45.42%
Leonardo DRS, Inc Common Stock (DRS)	2013-2016	-44.76%
BHP (BHP)	2013-2016	-44.54%
Mosaic (MOS)	2013-2016	-43.8%
Cameco (CCJ)	2013-2016	-43.34%

Large-cap stocks are treated as having a market cap of $10B+.