Canadian Pacific Railway (CP) had the lowest return in December 2008 by a large-cap US stock, returning -95.8%.

ASSET	MONTH	% RETURN
Canadian Pacific Railway (CP)	December 2008	-95.77%
Take-Two Interactive Software (TTWO)	December 2008	-36.52%
AerCap (AER)	December 2008	-31.44%
Insmed (INSM)	December 2008	-24.6%
Molina Healthcare (MOH)	December 2008	-24.55%
Ford Motor (F)	December 2008	-23.67%
Caseys General Stores (CASY)	December 2008	-22.5%
Cheniere Energy Partners (CQP)	December 2008	-22.23%
Revvity (RVTY)	December 2008	-20.51%
Leonardo DRS, Inc Common Stock (DRS)	December 2008	-20%
American International (AIG)	December 2008	-19.9%
Raymond James Financial (RJF)	December 2008	-18.89%
Regions Financial (RF)	December 2008	-18.68%
Lloyds Banking Group PLC ADR (LYG)	December 2008	-18.34%
EOG Resources (EOG)	December 2008	-18.32%
Lululemon Athletica (LULU)	December 2008	-17.74%
Dupont De Nemours (DD)	December 2008	-17.64%
American Express (AXP)	December 2008	-17.15%
Mettler-Toledo International (MTD)	December 2008	-15.64%
Agilent Technologies (A)	December 2008	-15.15%
Citigroup (C)	December 2008	-15.06%
FirstEnergy (FE)	December 2008	-14.74%
Electronic Arts (EA)	December 2008	-13.72%
Service Corporation International (SCI)	December 2008	-12.81%
Range Resources (RRC)	December 2008	-12.8%

Large-cap stocks are treated as having a market cap of $10B+.