QXO (QXO) had the highest return between 2010 and 2017 by a large-cap US stock, returning 4,956,500%.

ASSET	YEARS	% RETURN
QXO (QXO)	2010-2017	4,956,500%
Neurocrine Biosciences (NBIX)	2010-2017	2,701.08%
Domino's Pizza Inc Common Stock (DPZ)	2010-2017	2,436.6%
Netflix (NFLX)	2010-2017	2,320.38%
Cheniere Energy (LNG)	2010-2017	2,053.57%
XPO Logistics (XPO)	2010-2017	1,661%
United Rentals (URI)	2010-2017	1,632.97%
Jazz Pharmaceuticals (JAZZ)	2010-2017	1,570.6%
Tesla (TSLA)	2010-2017	1,538.64%
Broadcom (AVGO)	2010-2017	1,477.14%
Regeneron Pharmaceuticals (REGN)	2010-2017	1,450.99%
Texas Pacific Land Trust (TPL)	2010-2017	1,421.69%
EXACT Sciences (EXAS)	2010-2017	1,401.14%
Constellation Brands Inc Class A (STZ)	2010-2017	1,366.98%
Dycom Industries (DY)	2010-2017	1,270.6%
Align Technology (ALGN)	2010-2017	1,130.97%
Ulta Beauty (ULTA)	2010-2017	1,076.09%
NVIDIA (NVDA)	2010-2017	1,027.68%
Huazhu (HTHT)	2010-2017	999.35%
Take-Two Interactive Software (TTWO)	2010-2017	978.39%
Incyte (INCY)	2010-2017	927.22%
NetEase (NTES)	2010-2017	900.81%
Genmab A-S (GMAB)	2010-2017	892.57%
Transdigm (TDG)	2010-2017	885.72%
Monster Beverage (MNST)	2010-2017	882.28%

Large-cap stocks are treated as having a market cap of $10B+.