Monster Beverage (MNST) had the highest return between 2003 and 2007 by a large-cap US stock, returning 8,307.3%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2003-2007	8,307.29%
Cheniere Energy (LNG)	2003-2007	4,921.76%
Deckers Outdoor (DECK)	2003-2007	4,584.28%
Axon Enterprise (AXON)	2003-2007	4,163.7%
ArcelorMittal SA ADR (MT)	2003-2007	4,024.56%
Banco Bradesco SA ADR (BBD)	2003-2007	3,773.34%
Apple (AAPL)	2003-2007	2,659.27%
Intuitive Surgical (ISRG)	2003-2007	2,526.15%
Williams Companies (WMB)	2003-2007	2,493.2%
Vale SA ADR (VALE)	2003-2007	2,113.18%
Southern Copper (SCCO)	2003-2007	2,025.32%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2003-2007	1,997.51%
Akamai Technologies (AKAM)	2003-2007	1,822.22%
Grupo Cibest (CIB)	2003-2007	1,704.7%
Illumina (ILMN)	2003-2007	1,637.79%
CME (CME)	2003-2007	1,530.06%
Allegheny Technologies (ATI)	2003-2007	1,427.08%
U-Haul (UHAL)	2003-2007	1,377.47%
America Movil SAB de CV ADR (AMX)	2003-2007	1,273.94%
Tenaris SA ADR (TS)	2003-2007	1,237.47%
Itau Unibanco Banco (ITUB)	2003-2007	1,202.28%
GameStop (GME)	2003-2007	1,167.54%
Carpenter Technology (CRS)	2003-2007	1,166.8%
Ambev SA ADR (ABEV)	2003-2007	1,129.56%
Booking (BKNG)	2003-2007	1,081.69%

Large-cap stocks are treated as having a market cap of $10B+.