National Grid PLC ADR (NGG) had the highest return between 2004 and 2008 by a large-cap US stock, returning 1,018,952.9%.

ASSET	YEARS	% RETURN
National Grid PLC ADR (NGG)	2004-2008	1,018,952.94%
Natwest (NWG)	2004-2008	953,400%
Monster Beverage (MNST)	2004-2008	3,086.09%
Apple (AAPL)	2004-2008	692.27%
Intuitive Surgical (ISRG)	2004-2008	642.63%
Illumina (ILMN)	2004-2008	613.7%
Clean Harbors (CLH)	2004-2008	613.61%
Elbit Systems (ESLT)	2004-2008	505.7%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2004-2008	493.5%
Banco Bradesco SA ADR (BBD)	2004-2008	478.61%
First Solar (FSLR)	2004-2008	463.1%
Grupo Cibest (CIB)	2004-2008	442.91%
Stifel Financial (SF)	2004-2008	380.11%
Credicorp (BAP)	2004-2008	341.93%
Agnico Eagle Mines (AEM)	2004-2008	330.06%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2004-2008	325.08%
Ambev SA ADR (ABEV)	2004-2008	320.27%
Sterling Construction (STRL)	2004-2008	314.54%
Booking (BKNG)	2004-2008	308.03%
Alnylam Pharmaceuticals (ALNY)	2004-2008	305.41%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2004-2008	304.78%
Vale SA ADR (VALE)	2004-2008	297.44%
Nucor (NUE)	2004-2008	283.51%
Rogers Communications (RCI)	2004-2008	278.07%
Deckers Outdoor (DECK)	2004-2008	274.99%

Large-cap stocks are treated as having a market cap of $10B+.