QXO (QXO) had the highest return between 2011 and 2016 by a large-cap US stock, returning 3,450,050%.

ASSET	YEARS	% RETURN
QXO (QXO)	2011-2016	3,450,050%
Genmab A-S (GMAB)	2011-2016	1,128.34%
Regeneron Pharmaceuticals (REGN)	2011-2016	1,022.94%
Domino's Pizza Inc Common Stock (DPZ)	2011-2016	1,021.59%
Texas Pacific Land Trust (TPL)	2011-2016	749.97%
Tesla (TSLA)	2011-2016	696.13%
Ulta Beauty (ULTA)	2011-2016	655.33%
NVIDIA (NVDA)	2011-2016	639.11%
Cheniere Energy (LNG)	2011-2016	637.18%
Charter Communications (CHTR)	2011-2016	636.75%
Constellation Brands Inc Class A (STZ)	2011-2016	603.12%
Manhattan Associates (MANH)	2011-2016	589.6%
Tyler Technologies (TYL)	2011-2016	581.81%
Broadcom (AVGO)	2011-2016	576.8%
NetEase (NTES)	2011-2016	536.91%
Incyte (INCY)	2011-2016	505.5%
Booz Allen Hamilton (BAH)	2011-2016	467.94%
Diamondback Energy (FANG)	2011-2016	467.11%
Builders FirstSource (BLDR)	2011-2016	448.5%
Transdigm (TDG)	2011-2016	446.68%
Huntington Ingalls Industries (HII)	2011-2016	440.57%
Monolithic Power Systems (MPWR)	2011-2016	435.74%
Celsius (CELH)	2011-2016	432.75%
Smith AO (AOS)	2011-2016	432%
Expedia (EXPE)	2011-2016	410.36%

Large-cap stocks are treated as having a market cap of $10B+.