Celestica (CLS) has had the highest return between 2022 and 2025 by a large-cap US stock, returning 2,690.7%.

ASSET	YEARS	% RETURN
Celestica (CLS)	2022-2025	2,690.66%
Sterling Construction (STRL)	2022-2025	1,175.56%
Credo Technology (CRDO)	2022-2025	1,102.64%
Carpenter Technology (CRS)	2022-2025	1,078.01%
YPF Sociedad Anonima (YPF)	2022-2025	904.42%
Oklo (OKLO)	2022-2025	889.55%
Palantir Technologies (PLTR)	2022-2025	847.77%
Comfort Systems USA (FIX)	2022-2025	831%
Constellation Energy (CEG)	2022-2025	820.24%
Vistra Energy (VST)	2022-2025	723.27%
Super Micro Computer (SMCI)	2022-2025	716.41%
Ast Spacemobile (ASTS)	2022-2025	665.59%
TechnipFMC (FTI)	2022-2025	628.88%
Fortress Transp & Infra Inv (FTAI)	2022-2025	627.8%
Flex (FLEX)	2022-2025	616.5%
Insmed (INSM)	2022-2025	601.6%
Summit Therapeutics (SMMT)	2022-2025	595.87%
Vertiv (VRT)	2022-2025	581.69%
Robinhood Markets (HOOD)	2022-2025	578.67%
Howmet Aerospace (HWM)	2022-2025	543.13%
NVIDIA (NVDA)	2022-2025	539.03%
Allegheny Technologies (ATI)	2022-2025	520.29%
Madrigal Pharmaceuticals (MDGL)	2022-2025	516.44%
Applovin (APP)	2022-2025	487.05%
Symbotic (SYM)	2022-2025	480.64%

Large-cap stocks are treated as having a market cap of $10B+.