InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2001 and 2005 by a large-cap US stock, returning 9,399,400%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2001-2005	9,399,400%
National Grid PLC ADR (NGG)	2001-2005	700,019.05%
Monster Beverage (MNST)	2001-2005	4,035.77%
Cheniere Energy (LNG)	2001-2005	3,027.74%
Tractor Supply (TSCO)	2001-2005	2,390.84%
Sterling Construction (STRL)	2001-2005	1,749.45%
NetEase (NTES)	2001-2005	1,696.99%
Grupo Cibest (CIB)	2001-2005	1,606.76%
Clean Harbors (CLH)	2001-2005	1,517.45%
Hologic (HOLX)	2001-2005	1,344.57%
Royal Gold (RGLD)	2001-2005	1,132.92%
Axon Enterprise (AXON)	2001-2005	1,093.23%
Cameco (CCJ)	2001-2005	1,046.13%
ArcelorMittal SA ADR (MT)	2001-2005	1,017.78%
Apple (AAPL)	2001-2005	866.5%
CME (CME)	2001-2005	866.5%
Tapestry (TPR)	2001-2005	831.77%
Old Dominion Freight Line (ODFL)	2001-2005	809.84%
Chunghwa Telecom (CHT)	2001-2005	786.56%
Cognizant Technology Solutions Corp Class A (CTSH)	2001-2005	727.03%
Canadian Natural Resources (CNQ)	2001-2005	688.06%
Tenaris SA ADR (TS)	2001-2005	678.9%
Vale SA ADR (VALE)	2001-2005	644.16%
Western Digital (WDC)	2001-2005	626.3%
Intuitive Surgical (ISRG)	2001-2005	621.6%

Large-cap stocks are treated as having a market cap of $10B+.