First Solar (FSLR) had the highest return between 2000 and 2008 by a large-cap US stock in the Information Technology Sector, returning 463.1%.

ASSET	YEARS	% RETURN
First Solar (FSLR)	2000-2008	463.1%
Teledyne Technologies (TDY)	2000-2008	365.88%
Logitech International (LOGI)	2000-2008	351.18%
CACI International (CACI)	2000-2008	298.59%
Cognizant Technology Solutions Corp Class A (CTSH)	2000-2008	293.15%
Coherent (COHR)	2000-2008	273.62%
Apple (AAPL)	2000-2008	225.52%
Amphenol (APH)	2000-2008	186.89%
Western Digital (WDC)	2000-2008	169.41%
Trimble (TRMB)	2000-2008	161.95%
Autodesk (ADSK)	2000-2008	134.2%
Accenture (ACN)	2000-2008	128.13%
Salesforce (CRM)	2000-2008	113.4%
NVIDIA (NVDA)	2000-2008	105.1%
Manhattan Associates (MANH)	2000-2008	104.82%
Tyler Technologies (TYL)	2000-2008	99.67%
Genesis Healthcare (GEN)	2000-2008	81.02%
Frank's International (FI)	2000-2008	42.86%
Monolithic Power Systems (MPWR)	2000-2008	39.18%
Adobe Systems (ADBE)	2000-2008	27.53%
Wipro Limited ADR (WIT)	2000-2008	25.43%
Gartner (IT)	2000-2008	15.03%
Leidos (LDOS)	2000-2008	14.59%
Microchip Technology (MCHP)	2000-2008	9.45%
Fair Isaac (FICO)	2000-2008	9.02%

Large-cap stocks are treated as having a market cap of $10B+.