InterContinental Hotels Group PLC ADR (IHG) had the highest return between 1999 and 2003 by a large-cap US stock, returning 5,929,900%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	1999-2003	5,929,900%
Axon Enterprise (AXON)	1999-2003	1,076.79%
Laboratory Corporation of America (LH)	1999-2003	975%
NVR (NVR)	1999-2003	877.2%
Deckers Outdoor (DECK)	1999-2003	864.35%
Cognizant Technology Solutions Corp Class A (CTSH)	1999-2003	794.19%
Qualcomm (QCOM)	1999-2003	728%
Quest Diagnostics (DGX)	1999-2003	723.76%
Neurocrine Biosciences (NBIX)	1999-2003	679.14%
Tapestry (TPR)	1999-2003	654.99%
Pool (POOL)	1999-2003	629.21%
Logitech International (LOGI)	1999-2003	608.88%
Suzano Papel e Celulose SA ADR (SUZ)	1999-2003	554.26%
Coherent (COHR)	1999-2003	545%
Genesis Healthcare (GEN)	1999-2003	541.87%
Tractor Supply (TSCO)	1999-2003	536.53%
Chunghwa Telecom (CHT)	1999-2003	501.4%
Royal Gold (RGLD)	1999-2003	482.58%
CACI International (CACI)	1999-2003	478.38%
Southern Copper (SCCO)	1999-2003	473.8%
Gilead Sciences (GILD)	1999-2003	468.6%
East West Bancorp (EWBC)	1999-2003	460.85%
Teva Pharma Industries Ltd ADR (TEVA)	1999-2003	460.05%
Infosys Ltd ADR (INFY)	1999-2003	455.3%
Clean Harbors (CLH)	1999-2003	448.31%

Large-cap stocks are treated as having a market cap of $10B+.