Monster Beverage (MNST) had the highest return between 2000 and 2010 by a large-cap US stock, returning 9,668.4%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2000-2010	9,668.39%
Deckers Outdoor (DECK)	2000-2010	9,015.23%
Clean Harbors (CLH)	2000-2010	6,798.59%
Ambev SA ADR (ABEV)	2000-2010	3,928.28%
Banco Bradesco SA ADR (BBD)	2000-2010	3,876.25%
Southern Copper (SCCO)	2000-2010	3,374.33%
Altria (MO)	2000-2010	3,340.5%
Vale SA ADR (VALE)	2000-2010	2,679.2%
Alamos Gold (AGI)	2000-2010	2,357.57%
Tractor Supply (TSCO)	2000-2010	2,333.78%
Tapestry (TPR)	2000-2010	2,156.59%
Netflix (NFLX)	2000-2010	2,071.28%
Grupo Cibest (CIB)	2000-2010	1,966.42%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2000-2010	1,754.21%
Chunghwa Telecom (CHT)	2000-2010	1,747.21%
Cameco (CCJ)	2000-2010	1,740.07%
Tenaris SA ADR (TS)	2000-2010	1,734.56%
Teck Resources Ltd Class B (TECK)	2000-2010	1,613.28%
Royal Gold (RGLD)	2000-2010	1,564.64%
Cognizant Technology Solutions Corp Class A (CTSH)	2000-2010	1,495.43%
Old Dominion Freight Line (ODFL)	2000-2010	1,406.46%
Baidu (BIDU)	2000-2010	1,362.58%
NVR (NVR)	2000-2010	1,347.16%
Intuitive Surgical (ISRG)	2000-2010	1,332.02%
Canadian Natural Resources (CNQ)	2000-2010	1,317.95%

Large-cap stocks are treated as having a market cap of $10B+.