Genmab A-S (GMAB) had the highest return between 2013 and 2016 by a large-cap US stock, returning 1,084.5%.

ASSET	YEARS	% RETURN
Genmab A-S (GMAB)	2013-2016	1,084.47%
Netflix (NFLX)	2013-2016	810.2%
NVIDIA (NVDA)	2013-2016	807.25%
Celsius (CELH)	2013-2016	775.35%
Tesla (TSLA)	2013-2016	510.55%
Incyte (INCY)	2013-2016	499.7%
Broadcom (AVGO)	2013-2016	481.37%
Texas Pacific Land Trust (TPL)	2013-2016	458.81%
NetEase (NTES)	2013-2016	438.44%
Electronic Arts (EA)	2013-2016	433.24%
Diamondback Energy (FANG)	2013-2016	419.32%
Neurocrine Biosciences (NBIX)	2013-2016	403.91%
Burlington Stores (BURL)	2013-2016	398.53%
Southwest Airlines (LUV)	2013-2016	392.39%
Ubiquiti Networks (UI)	2013-2016	365.27%
Advanced Micro Devices (AMD)	2013-2016	344.71%
Huntington Ingalls Industries (HII)	2013-2016	340.58%
Take-Two Interactive Software (TTWO)	2013-2016	339.3%
Constellation Brands Inc Class A (STZ)	2013-2016	333.8%
DexCom (DXCM)	2013-2016	329.81%
Delta Air Lines (DAL)	2013-2016	323.9%
Facebook (META)	2013-2016	319.28%
Zillow (ZG)	2013-2016	313.47%
Best Buy (BBY)	2013-2016	299.97%
Domino's Pizza Inc Common Stock (DPZ)	2013-2016	278.27%

Large-cap stocks are treated as having a market cap of $10B+.