QXO (QXO) had the highest return between 2012 and 2016 by a large-cap US stock, returning 985,657.1%.

ASSET	YEARS	% RETURN
QXO (QXO)	2012-2016	985,657.14%
Genmab A-S (GMAB)	2012-2016	2,435.57%
Netflix (NFLX)	2012-2016	1,133.07%
Celsius (CELH)	2012-2016	1,066.71%
NVIDIA (NVDA)	2012-2016	702.01%
Texas Pacific Land Trust (TPL)	2012-2016	658.21%
Constellation Brands Inc Class A (STZ)	2012-2016	644.05%
Tesla (TSLA)	2012-2016	638.4%
Incyte (INCY)	2012-2016	566.25%
Broadcom (AVGO)	2012-2016	550.76%
Ionis Pharmaceuticals (IONS)	2012-2016	550.75%
Regeneron Pharmaceuticals (REGN)	2012-2016	549.6%
DexCom (DXCM)	2012-2016	527.1%
Delta Air Lines (DAL)	2012-2016	521.68%
NXP Semiconductors (NXPI)	2012-2016	521.1%
Huntington Ingalls Industries (HII)	2012-2016	506.25%
Southwest Airlines (LUV)	2012-2016	492.35%
Monolithic Power Systems (MPWR)	2012-2016	475.61%
Diamondback Energy (FANG)	2012-2016	467.12%
Builders FirstSource (BLDR)	2012-2016	422.38%
Domino's Pizza Inc Common Stock (DPZ)	2012-2016	422.2%
Zillow (ZG)	2012-2016	419.49%
NetEase (NTES)	2012-2016	417.29%
Manhattan Associates (MANH)	2012-2016	414.23%
Charter Communications (CHTR)	2012-2016	400.56%

Large-cap stocks are treated as having a market cap of $10B+.