Monster Beverage (MNST) had the highest return between 2003 and 2021 by a US stock in the S&P 500 (GSPC), returning 109,285%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2003-2021	109,284.97%
Apple (AAPL)	2003-2021	80,681.05%
Netflix (NFLX)	2003-2021	71,110.4%
Axon Enterprise (AXON)	2003-2021	46,418.52%
Deckers Outdoor (DECK)	2003-2021	33,098.31%
NVIDIA (NVDA)	2003-2021	31,945.96%
Tesla (TSLA)	2003-2021	27,709.24%
Intuitive Surgical (ISRG)	2003-2021	26,191.53%
Booking (BKNG)	2003-2021	24,583.48%
Align Technology (ALGN)	2003-2021	22,177.29%
Texas Pacific Land Trust (TPL)	2003-2021	18,365.82%
Amazon (AMZN)	2003-2021	17,275.41%
Old Dominion Freight Line (ODFL)	2003-2021	14,788.75%
Tyler Technologies (TYL)	2003-2021	12,957.04%
West Pharmaceutical Services (WST)	2003-2021	9,657.72%
Mastercard (MA)	2003-2021	9,484.65%
Johnson Controls International (JCI)	2003-2021	9,107.79%
Domino's Pizza Inc Common Stock (DPZ)	2003-2021	8,444.15%
IDEXX Laboratories (IDXX)	2003-2021	7,842.82%
Lam Research (LRCX)	2003-2021	7,262.68%
Salesforce (CRM)	2003-2021	6,676.77%
Akamai Technologies (AKAM)	2003-2021	6,402.22%
Monolithic Power Systems (MPWR)	2003-2021	6,069.57%
Edwards Lifesciences (EW)	2003-2021	6,044.76%
Transdigm (TDG)	2003-2021	5,978.96%